硫酸羟氯喹联合强的松治疗口腔黏膜扁平苔藓的临床疗效观察

目的:在口腔黏膜扁平苔藓的临床治疗过程中,探讨硫酸羟氯喹联合强的松的治疗效果。方法:主要选取2015年5月至2017年5月来我院接收治疗的口腔黏膜扁平苔藓患者,共66例,采用随机法分为两组,对照组实施硫酸羟氯喹治疗法,实验组在常规治疗前提下融入强的松进行治疗,比较两组的临床治疗效果、发生不良反应情况、红细胞沉降率。结果:经过治疗,实验组总有效率为97.0%,显著高于对照组的78.8%;在治疗时,实验组的不良反应发生率为6.1%;对照组的不良反应发生率为24.2%,实验组显著低于对照组。在VAS评分的比较上,两组患者均有所改善,但是实验组的优化幅度高于对照组,两组间差异均具有统计学意义(P<0.05)。结论:与单纯的应用硫酸羟氯喹治疗法相比,联合应用硫酸羟氯喹与强的松具有良好的效果,能够有效缓解疼痛程度,改善患者的症状,降低不良反应发生率,值得推广应用。

Objective: in the clinical treatment of oral lichen planus in study of hydroxychloroquine sulfate combined with prednisone treatment. Methods: from May 2016 to May 2017 to oral lichen planus patients in our hospital to receive treatment, a total of 66 patients were randomly divided into two groups, control group received the treatment of hydroxychloroquine sulfate method, the experimental group on the basis of conventional therapy with prednisone treatment, the clinical therapeutic effect of two groups were compared, the occurrence of adverse reactions, the erythrocyte sedimentation rate. Results: after treatment, the total efficiency of the experimental group was 97%, significantly higher than the control group 78.8%; at the time of treatment, adverse reactions of experimental group was 6.1%; adverse reaction rate in the control group was 24.2%, the experimental group was significantly lower than the control group. In the comparison of VAS score, two groups of patients were improved, but the experimental group was higher than that of the optimal range Control group, the difference between the two groups were statistically significant(P<0.05). Conclusion: compared with the application of hydroxychloroquine sulfate therapy alone, the combined application of hydroxychloroquine sulfate and prednisone has good effect, can effectively relieve pain, improve the symptoms of patients, reduce the incidence of adverse reactions, it is worthy of popularization and application.