白血病抑制因子在米非司酮流产妇女蜕膜组织中的表达研究

目的:探讨白血病抑制因子(leukemia inhibitory factor,LIF)在药物(米非司酮)流产妇女蜕膜组织中的表达。方法:用免疫组织化学方法对药流成功组(研究1组)、药流失败组(研究2组)、人工流产组(对照组)三组蜕膜组织LIF的表达进行检测,同时用JPEG采图系统采图和用HPIAS-1000高清晰度彩色病理图文报告分析系统测量程序检测和计算LIF表达灰度值。结果:LIF在蜕膜组织中的表达存在部位差异,LIF在腺体表达高于间质组织(P<0.01),在研究1组妇女蜕膜组织与研究2组妇女蜕膜组织、对照组妇女蜕膜组织的腺上皮之间灰度值差异有计学意义(P<0.05),在间质之间灰度值差异没统计学意义(P>0.05)。结论:LIF在蜕膜组织的表达存在部位差异。米非司酮导致流产可能与调节LIF分泌有关。

Objectives:To investigate and compare the expression of decidual LIF between early pregnancy and mifepristone induced abortion. Methods:By immunohistochemical analysis, the expressions of decidual LIF of the study 1 group and the study 2 group and the control group of mifepristone induced abortion were detected with quantitative analysis to the grey degree of immunohistochemical staining for LIF by HPIAS – 1000 and collected the pictures by JPEG system. Results:The grey degree of immunohistochemical staining for LIF of decidual cells in grandular epithelial cells is higher than in stroma cells(P<0.01). The compare of the grey degree of immunohistochemical staining for LIF of the study 1 group、the study 1 group and the control group have statistics significances(P<0.05)in grandular epithelial cells and have not statistics significances(P>0.05)in stroma cells. Conclusions:The expressions of decidual LIF make a difference in locations. It should be related to LIF for mifepristone induced abortion..