儿童呼吸道疾病与维生素D相关性分析

Analysis of correlation between respiratory tract disease and vitamin D levels

目的探讨儿童呼吸道疾病与维生素D缺乏的相关性。方法选取2016年1月至2017年12月在神木市医院儿科进行出院随诊的呼吸道疾病患儿186例为病例组,选取同期在儿童保健门诊健康查体的501例儿童作为对照组。采用化学发光免疫法测定两组的血清维生素D水平并进行比较,并分析组间维生素D缺乏/不足率。结果病例组血清维生素D水平为(20.99±18.10)ng/mL,低于对照组的(32.71±12.44)ng/mL,两组间差异有统计学意义(t=30.283,P<0.05)。病例组血清维生素D缺乏/不足发生率高于对照组(χ~2=44.998,P<0.01)。在不同年龄时期,对照组的维生素D水平均高于病例组(t值分别为10.021、13.321、19.901、11.372,均P<0.05),维生素D水平随年龄的增长而降低;在不同年龄时期,病例组的维生素D缺乏/不足发生率均高于对照组(χ~2值分别为12.887、12.043、7.272、12.214,均P<0.05)。在不同季节中,对照组的维生素D水平均高于病例组(t值分别为11.031、12.761、13.134、12.639,均P<0.05),病例组和对照组维生素D水平在夏季最高,冬季最低;病例组的维生素D缺乏/不足发生率均高于对照组(χ~2值分别为11.162、11.993、6.486、14.144,均P<0.05)。在城市和农村不同居住地,对照组的维生素D水平均高于病例组(t值分别为9.891、11.825,均P<0.05),在城市和农村病例组维生素D缺乏/不足发生率均高于对照组(χ~2值分别为25.696、18.652,均P<0.05)。Spearman相关性分析结果表明:呼吸道疾病发生率与维生素D水平呈正相关性(r=0.407,P<0.05),即维生素D水平越低,呼吸道疾病发生率越高。结论病例组患儿血清维生素D水平低于对照组,病例组患儿血清维生素D缺乏/不足发生率高于对照组。不同年龄时期、季节、居住地的病例组患儿血清维生素D水平均低于对照组,病例组患儿血清维生素D缺乏/不足发生率均高于对照组,维生素D缺乏与呼吸道疾病的发病存在相关性。

Objective To determine the correlation between vitamin D levels and respiratory disease.Methods 186 children with respiratory diseases admitted during the period from January 2016 to December 2017 were recruited as the case group and 501 children coming to the medical examination center of the hospital during the same period for health checkups were collected as the control group.The serum 25 hydroxyvitamin D levels in the two groups were measured by chemiluminescence immunoassay and were compared.The vitamin D deficiency/inadequacy rate between the two groups was compared.Results The serum vitamin D level in the study group was(20.99±18.10)ng/mL,lower than that in the control group(32.71±12.44)ng/mL,(P<0.05).The incidence of vitamin D deficiency/inadequacy in the study group was higher than that in the control group(χ~2=44.998,P<0.01).The incidence of vitamin D deficiency in the study group was higher than that in the control group,and the serum vitamin D level in each age group was lower than that in the control group.In four different seasons,the incidence of vitamin D deficiency in the study group was higher than that in the control group,and the vitamin D level in the study group was lower than that in the control group in each season.The level of vitamin D in the control group was higher than that in the study group,and the level of vitamin D in the urban group was lower than that in the rural group.The incidence of vitamin D deficiency/inadequacy in urban and rural study groups was higher than that in the control group.Vitamin D levels in the study group were lower than those in the control group.The results of Spearman correlation analysis showed that there was a positive correlation between the incidence of respiratory tract disease and vitamin D level(r=0.407,P<0.05),and that the lower the vitamin D level was,the higher the incidence of respiratory disease.Conclusion(1)The level of serum vitamin D in study group was lower than that in the control group,and the incidence of vitamin D deficiency in the study group was higher than that in the control group.(2)The levels of vitamin D in the study group were lower than those in the control group,and the incidence of vitamin D deficiency in the study group was higher than that in the control group.Vitamin D deficiency is associated with respiratory disease.