西替利嗪对急性哮喘发作儿童治疗效果的影响

Effect of cetirizine in the treatment of children with acute asthma

目的探讨西替利嗪对急性哮喘发作儿童治疗效果的影响。方法选择2018年2月至2019年2月间在台州市妇女儿童医院儿科诊治的94例急性哮喘发作患儿,依据随机数字表法分为观察组和对照组,每组47例。对照组给予布地奈德雾化治疗,观察组在对照组基础上加服西替利嗪口服溶液。于治疗前和治疗后观察记录两组患儿的肺功能指标、炎症因子水平,比较两组患儿的临床治疗效果,并观察不良反应发生情况。结果观察组患儿的治疗总有效率为93.62%,明显高于对照组的80.85%,差异具有统计学意义(χ~2=5.051,P<0.05)。治疗前,将两组患儿的肺功能指标以及炎症因子水平进行比较,差异无统计学意义(t值分别为1.029、0.827、 0.350、 0.222、0.215、 0.104、 0.137,均P>0.05);治疗后,观察组患儿的肺功能指标显著高于对照组(t值分别为19.057、21.230、5.369、15.046,均P<0.05),而炎症因子水平明显低于对照组(t值分别为5.603、4.866、6.258,P<0.05),差异有统计学意义。两组患儿的不良反应发生率比较无显著差异(χ~2=1.272,P>0.05)。结论西替利嗪治疗急性哮喘发作儿童临床效果较好,可有效降低炎症反应,改善肺功能。

Objective To explore the effect of cetirizine in the treatment of children with acute asthma.Methods 94 children with acute asthma admitted during the period from February 2018 to February 2019 in our hospital were studied.They were divided into the observation group(47 cases)and control group(47 cases)by the random number table method.The control group was given budesonide by atomization treatment.The observation group was given oral cetirizine on the basis of control group.The lung function indexes and inflammatory factor level of two groups were recorded and compared before and after treatment to compare the clinical efficacy and observe adverse reactions in the two groups.Results The total effective rate in the observation group was 93.62%,which was significantly higher than 80.85%in the control group(χ~2=5.051,P<0.05).There were no significant differences in lung function indexes and inflammatory factor level of two groups before treatment.After treatment,the pulmonary function index of the observation group was significantly higher than that of the control group(t=19.057,21.230,5.369,15.046,respectively,P<0.05),while the inflammatory factor level was significantly lower than that of the control group(t=5.603,4.866,6.258 respectively,P<0.05),and the difference was statistically significant.There was no significant difference in the incidence of adverse reactions between two groups(χ~2=1.272,P>0.05).Conclusion Cetirizine has a definitive clinical efficacy in the treatment of children with acute asthma,which can significantly improve lung function and reduce the inflammatory response.