产褥期颅内静脉窦血栓形成:1例报告及文献复习

Cerebral venous sinus thrombosis in puerperium: One case report and literature review

目的 :旨在探讨低分子肝素联合华法林治疗产褥期颅内静脉窦血栓的疗效。方法 :报道1例产褥期颅内静脉窦血栓形成患者的诊治经过,同时结合国内外相关文献对颅内静脉窦血栓形成的临床特征及诊治进展进行复习。结果 :患者在产褥期以头痛、呕吐起病,伴癫痫样发作;腰椎穿刺检测颅内压明显升高,头颅磁共振静脉造影(magnetic resonance venography,MRV)显示上矢状窦血栓形成。结合临床表现及辅助检查,诊断为颅内静脉窦血栓形成。给予低分子肝素联合华法林治疗后,病情得到有效控制。结论 :对颅内静脉窦血栓形成患者进行抗凝治疗是安全且有效的,必要时可行溶栓治疗。

Objective: To explore the effectiveness and safety of treatment with low molecular heparin combined with warfarin for patients diagnosed of cerebral venous sinus thrombosis(CVT) in puerperium.Methods: The clinical diagnosis and treatment of a patient with CVT in puerperium were reported.The clinical characteristics of CVT and the related progress in diagnosis and treatment of CVT were reviewed.Results: A patient suffered from headache,vomiting and seizure in puerperium.The lumbar puncture was conducted,showing significantly increased intracranial pressure.The superior magnetic resonance venography(MRV) showed superior sagittal sinus thrombosis.Based on clinical manifestations and examinations,this patient was diagnosed of CVT.Low molecular heparin combined with warfarin were given to the patient,and the condition was effectively controlled.Conclusion: For patients with CVT,anticoagulant therapy is safe and effective,and thrombolytic therapy is feasible when it is necessary.