丁苯酞对急性缺血性脑卒中患者神经功能缺损的改善效果分析

Clinical Improvement Study of Butylphthalide on Neurological Deficits in Patients with Acute Ischemic Stroke

目的研究丁苯酞对急性缺血性脑卒中患者神经功能缺损的改善效果。方法选取我院2016年1月～2017年3月期间收治的100例急性缺血性脑卒中患者作为研究对象,按照治疗方法将患者分成两组。对照组患者采用基础治疗方法,观察组在对照组的基础上给予患者丁苯酞治疗,以1个月为1个疗程。治疗1个疗程后比较两组患者神经功能缺损评分(NIHSS)、日常生活能力评分(Barthel指数)和出院后1年内患者病死率。结果两组患者在治疗1个疗程后较治疗前NIHSS评分都有所降低,Barthel指数评分都有所升高,但是观察组神经功能缺损评分(NIHSS)明显低于对照组,日常生活能力评分(Barthel指数)明显高于对照组,差异具有统计学意义(P<0.05);观察组死亡率18.00%,明显低于对照组死亡率40.00%,差异具有统计学意义(P<0.05)。结论丁苯酞治疗急性缺血性脑卒中患者能有效地改善神经功能缺损,提高患者日常生活的能力,降低了出院后患者的病死率,疗效肯定,值得临床推广应用。

Objective This study aimed to study the clinical improvement effects of butylphthalide on neurological deficits in patients with acute ischemic stroke Methods A total of 100 patients with acute ischemic stroke were selected from January 2016 to March 2017 in our hospital.Patients were divided into two groups according to different treatment methods.The control group was given the basic treatment,and the observation group was supplemented with the butylphthalide treatment.One month was taken as a course of treatment.After one course of treatment,the neurological deficit score(NIHSS),daily living ability score(Barthel index)and the mortality rate of all patients within 1year after discharge were observed and compared.Results The patients of two groups had lower NIHSS scores and higher Barthel index scores after one course of treatment,but the neurological deficit score(NIHSS)of the observation group was significantly lower than that of the control group,and the daily living ability score(Barthel index)of the observation group was significantly higher than that of the control group(P<0.05).The mortality rate of the observation group was significantly lower than that of the control group(18.0% vs 40.0%,P<0.05).Conclusion Butylphthalide can effectively improve neurological deficits of acute ischemic stroke patients,improve patients’ daily living ability,and reduce the mortality rate of patients after discharge.This method have certain effect,which is worthy of clinical application.