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两种抗真菌药治疗外耳道真菌病的疗效比较 被引量:2

Observation on the Efficacy of two Antifungals in the Treatment of Otomycosis
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摘要 目的比较布替萘芬搽剂及酮康唑霜治疗外耳道真菌病的疗效。方法选择2016年1月至2017年8月我院收治的92例外耳道真菌病患者作为研究对象,将其随机分为观察组(42例)和对照组(50例)。观察组患者采用布替萘芬搽剂耳浴治疗,对照组患者采用酮康唑霜涂药治疗。比较两组患者的临床疗效。结果患者有娱乐场所'采耳'史或共用'挖耳匙'等流行病学史者65例(占70.65%,65/92);所有患者具有不同程度的耳痒、耳闷、耳鸣、听力下降、耳道分泌物等不典型症状,部分还伴有脚癣、体癣及甲真菌病(占50.00%,46/92);经治疗后,观察组患者治疗有效率为85.71%(36/42),与对照组治疗有效率为88.00%(44/50)比较,差异无统计学意义(χ~2=0.105,P=0.746)。结论布替萘芬搽剂及酮康唑霜剂这两种不同药物成分及不同剂型的抗真菌药物对外耳道真菌病治疗疗效相当,临床可根据具体情况选择用药。 Objective This study aimed to compare the efficacy of Butenafine Hydrochloride Liniment and ketoconazole cream in the treatment of otomycosis.Methods A total of 92 patients with otomycosis from January 2016 to August 2017 in our hospital were randomly divided into observation group(42 cases)and control group(50 cases).Observation group was treated with butranafine Hydrochloride liniment ear bath.The control group was treated with ketoconazole cream.All patients received therapy with 2 times a day,continuous medication for 14 days,and the efficacy of two groups was compared.Results Among 92 patients,65(70.65%,65/92)had the history of'ear-picking'in entertainment places or shared the history of'ear-picking keys'.All patients had atypical symptoms such as ear itching,ear tightness,tinnitus,hearing loss,ear canal secretions,and some were accompanied by tinea pedis,tinea corporis and onychomycosis(50.00%,46/92).After treatment,31 cases were cured,5 cases were improved,the effective rate was 85.71%(36/42)in the observation group;40 cases were cured,4 cases were improved,the effective rate was 88.00%(44/50)in the control group.There was no significant difference between the two group(χ~2=0.105,P=0.746).Conclusion Butenafine Hydrochloride Liniment and ketoconazole cream with different components and dosage forms are both effective in the treatment of otomycosis,which drug to choose depends on the specific situation in clinic.
作者 王平 杨秋 陈燕玲 黄常明 奚益平 王嘉川 Wang Ping;Yang qiu;Chen Yanling;Huang Changming;Xi Yiping;Wang Jiachuan(Nuclear Industry 416 Hospital,Department of Otolaryngology of the 2nd Affiliated Hospital of Chengdu Medical College,Chengdu610051,China;Nuclear Industry 416 Hospital,Department of Dermatology of the 2nd Affiliated Hospital of Chengdu Medical College,Chengdu610051,China;Nuclear Industry 416 Hospital,Department ofoccupational medicine of the 2nd Affiliated Hospital of Chengdu Medical College,Chengdu610051,China;Nuclear Industry 416 Hospital,Department of Infectious Diseases of the 2nd Affiliated Hospital of Chengdu Medical College,Chengdu610051,China)
出处 《四川解剖学杂志》 2019年第2期4-6,共3页 Sichuan Journal of Anatomy
关键词 外耳道真菌病 布替萘芬搽剂 酮康唑霜 疗效 Otomycosis external Butenafine Hydrochloride Liniment Ketoconazole Cream curative effect
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