摘要
The synthesis of triple hydrogen-bonding block copolymers by sequential reversible addition-fragmentation chain transfer(RAFT) polymerizations was explored. In combination with 1-octylthymine as mediator, the amphiphilic triple hydrogen-bonding block copolymers with Mn up to 24,900 Da and relatively broader molecular weight distribution were obtained. Micelles with hydrophobic core and hydrophilic corona could be fabricated by self-assembling of the corresponding block copolymer in water. Transmission electron microscopy and laser light scattering studies show that the micelles are in nano-scale with narrow size distribution. The obtained polymeric micelle with triple hydrogen-bonding unit could be used in biomedical materials field such as carrier of hydrophilic drug.
本文以1-辛烷基胸腺嘧啶为调节剂,通过RAFT聚合合成了含有三重氢键的两亲性嵌段聚合物(PBA-b-PDAD).凝胶渗透色谱测试表明,PBA-b-PDAD的数均分子量可达24,900 Da,并具有相对较宽的分子量分布.PBA-b-PDAD可在水溶液中组装成具有核壳结构的球形胶束.透射电镜和动态光散射研究表明,该球形胶束的粒径在50 nm左右.此类含三重氢键的球形胶束,在生物材料以及药物缓释领域具有潜在的应用价值.
基金
supported by the National Natural Science Foundation of China(21304085)
