恩替卡韦联合抗病毒方治疗慢性乙型肝炎

Investigation the Effects of Entecavir Plus Antiviral Decoction Combination Therapy for Chronic Hepatitis B

目的观察恩替卡韦(ETV)与自拟抗病毒方联合用药治疗慢性乙型肝炎(CHB)的临床疗效。方法将60例CHB患者随机分为对照组和治疗组各30例,对照组单用ETV进行治疗,而治疗组在对照组用药基础上,加用抗病毒方进行治疗。两组均连续用药24周。药物的疗效通过ALT复常率、HBe Ag及HBV-DNA转阴率来评价。结果两组经治疗后,治疗组ALT复常率、血清HBe Ag及HBV-DNA转阴率分别为74.1%、15.7%、61.1%,与对照组66.2%、11.2%、58.5%相比较差异均有统计学意义(P<0.05)。结论 ETV与抗病毒方联合治疗CHB疗效优于单纯ETV治疗,其临床应用价值较高,值得推广。

Objective To observe the clinical efficacy of Self-made antiviral decoction combined with entecavir( ETV) on treating chronic hepatitis B( CHB) for 24 weeks. Methods Sixty CHB patients were assigned to two groups : the observation group( the self-made antiviral decoction combined with ETV treatment group) and the control group( the ETV control group). The alanine aminotransferase( ALT),the levels of serum hepatitis B virus-DNA( HBV-DNA) and HBe Ag negative conversion rate were tested before and after treatmen. Results In the two groups after treatment,the alanine aminotransferase( ALT),the levels of serum hepatitis B virus-DNA( HBV-DNA) and HBe Ag negative conversion rate of the observation group are 74. 1%,15. 7% and74. 1% respectively,compared with the control group 66. 2%,11. 2%,58. 5%,with significant difference( P < 0. 05). Conclusion ETV and Self-made Antiviral decoction combined treatment of CHB efficacy is better than that of pure ETV treatment,the clinical application value is high,is worth promoting.