幽门螺杆菌感染与慢性阻塞性肺疾病关系探讨

The Relationship between HP Infection and COPD

目的探讨幽门螺杆菌(HP)感染和慢性阻塞性肺疾病(COPD)的关系。方法通过174例COPD患者和185例健康人群的14C尿素呼气试验,比较两组HP感染的阳性率。比较174例COPD患者中HP感染阳性和阴性的两组患者的肺功能和血气分析情况。结果 COPD组的HP阳性率为69/174例(39.66%),健康人群为56/185例(30.27%),两组比较差异有统计学意义(P<0.05)。肺功能检测结果 HP感染阳性的COPD患者第1秒最大呼气量(FEV1)、用力肺活量(FVC)及FEV1/FVC值明显低于HP阴性的COPD患者;血气分析结果为HP阳性COPD组的血氧分压(Pa O2)和血氧饱和度(Sa O2)水平低于阴性的COPD患者,而Pa CO2水平高于阴性的COPD患者。结论 COPD组的HP感染率高于正常人群组,HP感染与COPD的病情严重程度密切相关。

Objective To discuss the relationship between helicobacter pylori( HP) infection and chronic obstructive pulmonary disease( COPD). Methods To compare the rate of HP infection in 174 patients with COPD and 185 healthy people through the 14C-urea breath testl; To compare the results of lung function and blood gas analysis in the 174 COPD patients with HP( +) and HP(-). Results The rate of HP infection was 69 /174( 39. 66) in COPD group vs. 56 /185( 30. 27%) in healthy people,there was significant difference between the two groups. Pulmonary function tests showed the FEV1,FVC,FEV1/ FVC in COPD patients with HP( +) was significantly lower than in the COPD patients with HP(-). Blood gas analysis showed that the level of Pa O2 and Sa O2 was lower in the COPD patients with HP( +) than in the COPD patients with HP(-),and the COPD patients with HP( +) had a higher Pa CO2 level. Conclusion HP infection rate is higher in the COPD group than in the general population,HP infection is closely related to disease severity of COPD.