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Th17细胞在类风湿关节炎中作用的研究进展 被引量：2

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摘要 辅助性T细胞17(T Helper 17 cell,Th17)是一种新发现的由初始CD4+T细胞产生并以分泌IL-17为主的细胞亚群,它与Th1和Th2以及调节性T细胞(Treg)细胞亚群均有不同之处,具有独立的分化和发育调节机制,能够促进自我防御、炎性反应及自身免疫应答功能。类风湿关节炎(rheumatiod arthritis,
作者 李婧 商玮 蔡辉
机构地区 安徽中医药大学 南京军区南京总医院中西医结合科
出处 《四川医学》 CAS 2015年第2期243-245,共3页 Sichuan Medical Journal
基金 南京军区南京总医院科研基金资助项目(编号:2012010)
关键词 TH17细胞 类风湿关节炎 细胞因子 文献综述
分类号 R593.22 [医药卫生—内科学]
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参考文献17

  • 1SY Hwang,JY Kim,KW Kim,MK Park,Y Moon,WU Kim,HY Kim.IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways. Arthritis research & therapy . 2004
  • 2Wu Yan,Zhu Lingxin,Wei Hongxia,Peng Bin.Regulation of Matrix Metalloproteinases, Tissue Inhibitor of Matrix Metalloproteinase-1, and Extracellular Metalloproteinase Inducer by Interleukin-17 in Human Periodontal Ligament Fibroblasts. Journal of Endodontics . 2012
  • 3Parsonage Greg,Filer Andrew,Bik Magdalena,Hardie Debbie,Lax Sian,Howlett Katherine,Church Leigh D,Raza Karim,Wong See-Heng,Trebilcock Emily,Scheel-Toellner Dagmar,Salmon Mike,Lord Janet M,Buckley Christopher D.Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha. Arthritis research & therapy . 2008
  • 4Murthy RK,Morrow PK,Theriault RL.Bone biology and therole of the RANK ligand pathway. Oncology (WillistonPark) . 2009
  • 5Fujikawa Y,Quinn J M,Sabokbar A,et al.The human osteoclast precursor circulates in the monocyte fraction. The Journal of Endocrinology . 1996
  • 6Sougata Karmakar,Jonathan Kay,Ellen M. Gravallese.Bone Damage in Rheumatoid Arthritis: Mechanistic Insights and Approaches to Prevention[J]. Rheumatic Disease Clinics of North America . 2010 (2)
  • 7Melanie A. Kleinschek,Alex,er M. Owyang,Barbara Joyce-Shaikh,Claire L. Langrish,Yi Chen,Daniel M. Gorman,Wendy M. Blumenschein,Terrill McClanahan,Frank Brombacher,Stephen D. Hurst,Robert A. Kastelein,Daniel J. C.IL-25 regulates Th17 function in autoimmune inflammation. The Journal of Experimental Medicine . 2007
  • 8Xiaoyin Niu,Dongyi He,Xin Zhang,Tao Yue,Ningli Li,Jingwu Z. Zhang,Chen Dong,Guangjie Chen.IL-21 regulates Th17 cells in rheumatoid arthritis[J]. Human Immunology . 2010 (4)
  • 9Shihoko Tanigawa,Yukiko Aida,Takayuki Kawato,Kazuhiro Honda,Go Nakayama,Masafumi Motohashi,Naoto Suzuki,Kuniyasu Ochiai,Hideo Matsumura,Masao Maeno.Interleukin-17F affects cartilage matrix turnover by increasing the expression of collagenases and stromelysin-1 and by decreasing the expression of their inhibitors and extracellular matrix components in chondrocytes[J]. Cytokine . 2011 (2)
  • 10Fuliang Bai,Hui Tian,Zeshan Niu,Mingyao Liu,Guiping Ren,Yinhang Yu,Tian Sun,Siming Li,Deshan Li.Chimeric anti-IL-17 full-length monoclonal antibody is a novel potentialcandidate for the treatment of rheumatoid arthritis[J]. International Journal of Molecular Medicine . 2014 (3)

二级参考文献78

共引文献47

同被引文献49

引证文献2

二级引证文献9

四川医学
2015年 第2期

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