透脓散对肛周脓肿术后模型创面愈合的实验研究

Experimental Research of Tounong Powder on Wound Healing of Rat' s Perianal Abscess

目的:观察透脓散对大鼠肛周脓肿术后模型创面愈合的影响。方法:24只SD大鼠随机分为透脓散组、黄连解毒汤组,制备大鼠脓肿创面模型,药物干预后,分别于造模后第3、7、14天取创面肉芽组织,观察病理变化。结果:透脓散组在造模第3、7、14天时创面的愈合率明显高于对照组,在创面愈合早期(3~7天),透脓散组成纤维细胞数量大于黄连解毒汤组(P<0.05),在第7天时血管增生情况优于对照组。结论:透脓散促进成纤维细胞的增生及肉芽组织的生长,缩短了创面的愈合时间,提高创面的愈合率。

Objective: To explore the effect of Tounong Powder on wound healing of rat's perianal abscess. Methods: 24SD rats were randomly divided into two groups: Tounong Powder group and Huanglian Jiedu Decoction group. After the wound of the rat' s perianal abscess was manufactured and treated with medicine,the granulation tissue in the wound was cut on the 3th,7th,14th day and pathological changes were observed. Results: On the 3rd,7th,14th day after modeling of Tounong Powder group,the wound healing rate was significantly higher than the controlled group. In the initial wound healing stage( 3 ~ 7d),there were more fibroblasts on the wound of Tounong Powder group than on Huanglian Jiedu Decoction group( P <0. 05). There were more blood capillaries at the 7thday than the controlled group. Conclusion: Tounong Powder can promote fibroblast proliferation and granulation tissue growth,and shorten the healing time,improve wound healing.