中西医结合治疗结节性红斑疗效观察及对血清丙种球蛋白和血沉的影响

Curative Observation of Applying Integrative Medicine to Treat Erythema Nodosum and the Impact on Serum Globulin and ESR

目的:观察中西医结合治疗结节性红斑患者临床疗效观察及对血清丙种球蛋白、血沉的影响。方法:97例结节性红斑患者按照随机数字表法随机分为对照组(n=48)和治疗组(n=49)。对照组给予西药治疗,治疗组在对照组基础上结合中药治疗。两组疗程均为4周。对比分析两组疗效,主要症状积分、血清丙种球蛋白和血沉水平变化,不良反应及随访3个月复发情况。结果:治疗组治疗4周后总有效率(95.92%)显著高于对照组(79.17%)(P<0.05);两组治疗后主要症状(包括丘疹、疼痛、血疱、多形性红斑结节)积分较治疗前明显减少(P<0.05);治疗组治疗后主要症状(包括丘疹、疼痛、血疱、多形性红斑结节)积分明显低于对照组(P<0.05);两组治疗后血清丙种球蛋白、血沉水平较治疗前显著减少(P<0.05);治疗组治疗后血清丙种球蛋白、血沉水平显著低于对照组(P<0.05);治疗期间两组均未见明显不良反应;两组疗程结束后随访3个月复发率比较无统计学差异(P>0.05)。结论:中西医结合治疗结节性红斑患者临床疗效显著,可明显降低血清丙种球蛋白、血沉水平,且无明显不良反应发生,复发率低,临床应用安全可靠,具有重要研究意义,值得进一步推广应用。

Objective: To investigate the clinical efficacy of combination therapy was observed in patients with erythema nodosum serum gamma globulin,influence and erythrocyte sedimentation rate. Methods: 97 cases of patients with erythema nodosum according to the random number table,randomly divided into controlled group( n = 48) and treatment group( n = 49). The controlled group received western medicine,the treatment group received traditional Chinese medicine on the basis of the controlled group. The treatment lasted four weeks. Comparative analysis of the two groups,the main symptom score,serum gamma globulin levels and erythrocyte sedimentation rate,adverse reactions and three-month follow-up recurrence. Results: The total effective rate( 95. 92%) after 4 weeks of the treatment group was significantly higher than before treatment( 79. 17%)( P <0. 05); after treatment,the main symptoms( including rash,pain,blood blisters,erythema multiforme nodules) score was lower than before treatment,the difference was significant( P < 0. 05); after treatment,the main symptoms( including rash,pain,blood blisters,erythema multiforme nodules) score of the treatment group was significantly lower than the controlled group( P < 0. 05); the serum globulin,erythrocyte sedimentation rate levels than before treatment significantly reduced( P < 0. 05);serum globulin,erythrocyte sedimentation rate levels of the treatment group after treatment was significantly lower than the controlled group( P < 0. 05); during the treatment of the two groups showed no significant adverse reactions; the recurrence rate was no significant difference( P > 0. 05) after the end of three months follow-up. Conclusion: The clinical efficacy of applying combination therapy in patients with erythema nodosum is significant,can significantly reduce serum gamma globulin,ESR levels,and no significant adverse events,recurrence rate,clinical application of safe and reliable,has great significance,worthy of further popularization and application.