天麻温胆汤加减联合依那普利叶酸片治疗H型高血压(痰瘀互结型)临床观察

Clinical Observation of Tianma Wendan Decoction Combined with Enalapril and Folic Acid Tablets for Treating Type H Hypertension (Phlegm and Blood Stasis Type)

目的:研究天麻温胆汤加减联合依那普利叶酸片治疗H型高血压(痰瘀互结型)临床疗效。方法:选取我院2015年7月~2016年7月痰瘀互结型H型高血压患者120例,按照入院顺序编号采取随机数表法将患者分为观察组与对照组两组,每组60例,给予对照组患者依那普利叶酸片治疗,观察组在对照组基础上联合天麻温胆汤治疗,比较两组患者临床疗效,比较治疗前后血压、Hcy水平以及肿瘤坏死因子(TNF-α)、超敏C反应蛋白(Hs-CRP)、白介素-6(IL-6)等炎性因子水平。结果:观察组患者临床治疗总有效率为95.00%较对照组81.67%显著较高(P<0.05);观察组治疗后收缩压、舒张压以及Hcy水平较对照组显著较低(P<0.05);治疗后观察组TNF-α、Hs-CRP、IL-6水平较对照组显著降低(P<0.05)。结论:天麻温胆汤加减联合依那普利叶酸片能有效控住痰瘀互结型H型高血压患者血压水平,改善其临床症状,降低Hcy及炎性因子水平,中西联合用药较单纯西药治疗疗效更显著,值得临床应用推广。

Objective: To study the clinical curative effect of using Tianma Wendan Decoction combined with enalapril in the treatment of hypertension( Folic Acid Tablets H phlegm and blood stasis type). Methods: In our hospital from July 2015 to July 2016,120 cases of phlegm and blood stasis in patients with type H type hypertension,according to the order of admission number taken randomly were divided into observation group and controlled group,60 cases in each group,the controlled group was given enalapril treatment of Folic Acid Tablets,the observation group was given Tianma Wendan Decoction on the basis of the controlled group,compared the clinical efficacy of the two groups before and after treatment,blood pressure,the level of Hcy and tumor necrosis factor( TNF-α),high sensitive C reaction protein( Hs-CRP),interleukin-6( IL-6) and other inflammatory cytokines. The total effective rate of the observation group was 95%,and it is significantly higher than the controlled group which was 81. 67%( P<0. 05); the observation group after treatment,systolic blood pressure,diastolic blood pressure and the level of Hcy was significantly lower than the controlled group( P < 0. 05); TNF-alpha,Hs-CRP,IL-6 after treatment of the observation group,was significantly lower than the controlled group( P<0. 05). Conclusion: Tianma Wendan Decoction combined with enalapril and Folic Acid Tablets can effectively control the phlegm and blood pressure levels in patients with type H hypertension,improve the clinical symptoms,reduce the level of Hcy and inflammatory factors,the combination of traditional Chinese medicine and western medicine is more effective than simple western medicine treatment,worthy of clinical application