自拟胃安方对气虚血瘀型慢性萎缩性胃炎患者胃黏膜保护作用的初步研究

Preliminary Study of Self-made Wei'an Recipe for Qi-deficiency and Blood-stasis Type Chronic Atrophic Gastritis Patients on the Effect of Gastric Mucosal Protection

目的:探讨自拟胃安方治疗慢性萎缩性胃炎的治疗效果及其对超氧化物歧化酶(SOD)、丙二醛(MDA)及谷胱甘肽(GSH-PX)的影响。方法:选取慢性萎缩性胃炎患者患者103例,随机分为对照组和观察组,对照组患者多潘立酮1片/次,3次/天;阿莫西林胶囊0.5g/次,3次/天;胃痛较剧烈加服铝碳酸镁片2片/次,3次/天,疗程1个月,连续2疗程。观察组采用自拟胃安方治疗,每日1剂,分早晚2次温服,疗程1个月,连续2疗程。将2组患者治疗前后血清中SOD、MDA及GSH-Px的含量进行检测及统计分析,比较2组治疗后内镜下临床疗效、幽门螺杆菌检测结果及不良反应。结果:治疗后2组患者的MDA表达明显降低(P<0.05),SOD及GSH-Px的表达均明显升高(P<0.05),并且治疗后观察组患者MDA水平低于对照组,具有明显差异(P<0.05),SOD及GSH-Px的水平高于对照组,具有明显差异(P<0.05);对照组内镜下胃黏膜疗效总有效率为80.2%,观察组为94.3%,2组胃黏膜疗效比较差异显著(P<0.05);2组临床疗效比较,对照组的总有效率为70.8%,而观察组的治疗总有效率为92.5%,差异显著(P<0.05);2组治疗后观察组Hp检测显阴性者49例,对照组Hp检测显阴性者39例,2组比较有显著性差异(P<0.05)。结论:自拟胃安方治疗慢性萎缩性胃炎具有良好的临床疗效,其治疗机制可能是清除自由基抗氧化作用。

Objective: To investigate the effect of using Self-made Wei' an Recipe in the treatment of chronic atrophic gastritis and its therapeutic effect on superoxide dismutase( SOD),malondialdehyde( MDA) and glutathione( GSH-PX) effect.Methods: 103 cases of patients with chronic atrophic gastritis were randomly divided into controlled group and observation group,patients in the controlled group was given 1 Domperidone tablet/time,3 times/d; Amoxicillin Capsules 0. 5g/,3 times/d; stomach pain more severe with Hydrotalcite Tablets 2/times,3 times/d,1 months of treatment,continuous the 2 courses of treatment. The observation group was treated with Self-made Wei' an Recipe treatment,daily 1agent,and the 2 day,after 1 months of treatment,continuous treatment of 2 courses. The serum levels of SOD,MDA and GSH-Px were detected and statistically analyzed before and after treatment in the 2 groups,and the clinical efficacy,Helicobacter pylori test results and adverse reactions were compared between the 2 groups after treatment. Results: 2 groups of patients with MDA expression were significantly decreased after treatment( P<0. 05),the expression of SOD and GSH-Px were significantly increased( P<0. 05),and MDA of the observation group were lower than those of the controlled group after treatment,with significant difference( P<0. 05),SOD and GSH-Px levels higher than the controlled group,with significant the difference( P<0. 05); The total effective rate of the controlled group of endoscopic gastric mucosal was 80. 2%,the observation group was 94. 3%. The difference in efficacy of gastric mucosa of the 2 group was significant( P<0. 05); To compare the clinical efficacy of the 2 groups,the total effective rate of the controlled group was 70. 8%,while the total effective rate of the treatment group was 92. 5%,the difference was significant difference( P<0. 05);After treatment of the 2 groups,49 cases of Hp detection were negative in the observation group,39 cases of the controlled group were negative Hp test,there were significant differences between the 2 groups( P<0. 05). Conclusion: Self-made Wei' an Recipe has good clinical efficacy in the treatment of chronic atrophic gastritis and its therapeutic mechanism may be the effects of free radical scavenging antioxidant.