茵陈蒿汤加味配合桑芎胶囊治疗肺胃湿热型痤疮的疗效及对血清TNF-α、IL-8和相关性激素水平的影响

Curative Effect of Modified Yinchenhao Decoction Combined with Sangxiong Capsule for Patients with Lung-stomach Damp-heat Type Acne and Influence on Serum TNF-α,IL-8 and Related Hormone Levels

目的:观察茵陈蒿汤加味配合桑芎胶囊对肺胃湿热型痤疮患者疗效、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)及相关性激素水平的影响。方法:选取我院收治的肺胃湿热型痤疮患者128例作为研究对象,按照随机数字表法分为观察组和对照组各64例,2组均给予健康教育、饮食指导,在此基础上对照组给予桑芎胶囊治疗,观察组在对照组基础上配合茵陈蒿汤加味治疗。观察2组中医症候积分、临床疗效、皮损严重程度,检测血清TNF-α、IL-8、卵泡刺激素(FSH)、睾酮(T)、黄体生成素(LH)、雌二醇(E2)水平。结果:治疗后2组中医症候积分显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05);观察组总有效率93.75%显著高于对照组81.25%(P<0.05);治疗后2组皮损评分显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05);治疗后2组血清TNF-α、IL-8水平显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05);治疗后2组FSH、LH、E2水平与治疗前比较差异无统计学意义(P>0.05),2组T水平显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05)。结论:茵陈蒿汤加味配合桑芎胶囊可有效改善肺胃湿热型痤疮患者血清TNF-α、IL-8水平和相关性激素水平,提高临床疗效。

Objective: To observe the curative effect of Yinchenhao Decoction combined with Sangxiong Ccapsule on serum tumor necrosis factor α(TNF-α) and interleukin-8(IL-8) and related hormone levels for patients with lung-stomach dampheat type acne. Methods: 128 cases of patients with lung-stomach damp-heat type acne treated in our hospital were selected as the study objects,and were divided into observation group and controlled group according to random number table method,64 cases in each group. All the two groups were given health education and dietary guidance,on the basis of that,the controlled group were given Sangxiong Capsule treatment,and the observation group were combined with Yinchenhao Decoction on the basis of the controlled group. TCM symptom score,clinical efficacy,skin lesion severity were observed in the two groups,and serum TNF-α,IL-8,follicle stimulating hormone(FSH),testosterone(T),luteinizing hormone(LH) and estradiol(E2) levels were detected in the two groups. Results: After treatment,TCM symptoms scores were significantly lower than those before treatment in the two groups(P<0. 05),and those in the observation group were significantly lower than those in the controlled group(P<0. 05). The total effective rate of the observation group was 93. 75%,significantly higher than that of the control group which was 81. 25%(P< 0. 05). After treatment,the score of skin lesions was significantly lower than that before treatment in the two groups(P <0. 05),and that in the observation group was significantly lower than that in the controlled group(P<0. 05). After treatment,serum TNF-α and IL-8 levels were significantly lower than those before treatment in the two groups(P< 0. 05),and those in the observation group were significantly lower than those in the controlled group(P<0. 05). The levels of FSH,LH and E2 were not significantly different from those before treatment in the two groups(P>0. 05). T was significantly lower than that before treatment in the two groups(P<0. 05),and that in the observation group was significantly lower than that in the controlled group(P <0. 05). Conclusion: Yinchenhao Decoction combined with Sangxiong Capsule can effectively improve serum TNF-α and IL-8 levels in patients with lung stomach damp heat type acne,and related hormone levels. It can improve clinical efficacy.