双黄通络饮对糖尿病周围神经病变及其NCV的影响

Effect of Shuanghuang Tongluo Decoction for Diabetic Peripheral Neuropathy as well as NCV

目的:观察双黄通络饮对气虚血瘀型糖尿病周围神经病变(DPN)患者神经传导速度(NCV)的影响以及临床疗效。方法:将68例DPN患者随机分为两组,对照组(34例):硫辛酸注射液300mg加入250ml生理盐水静脉滴注,每日一次;治疗组(34例):口服双黄通络饮汤剂,日1剂,疗程均为2周。观察两组治疗前后症状的改善以及患者NCV指标变化情况。结果:治疗组总有效率分别为85.3%、79.4%,治疗组显著高于对照组(P<0.05)。组间比较NCV改善基本相当(P>0.05)。结论:双黄通络饮治疗DPN疗效肯定,对患者神经传导速度的影响与硫辛酸一致。

Objective:To observe the effect of Shuanghuang Tongluo Decoction on NCV in patients with DPN of Qi deficiency and blood stasis type and its clinical efficacy.Methods:68 patients with DPN were randomly divided into two groups.The controlled group(34 cases):Thioctic Acid Injection 30 mg joined 250 ml normal saline,qd,intravenous injection.The treatment group(34 cases):Shuanghuang Tongluo Decoction,bid,taken orally.The two groups were all treated for 2 weeks.The two groups were observed before and after treatment in symptomatic improvement and changes of NCV indexes.Results:The total effective rate of the treatment group and the controlled group were 85.3%and 79.4%respectively,but the NCV improvement between the two groups were basically equivalent(P<0.05).Conclusion:The curative effect is certain of Treating DPN with Shuanghuang Tongluo Decoction.Its effect on nerve conduction velocity is consistent with lipoic acid.