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PCR-SSCP检测肺癌PTEN基因的点突变 被引量:1

PCR-SSCP in Detection of PTEN Gene Point Mutation in Lung Carcinoma
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作者 徐龙 倪培华
出处 《诊断学理论与实践》 2003年第3期223-224,共2页 Journal of Diagnostics Concepts & Practice
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参考文献10

  • 1[1]Li DM, Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta [J]. Cancer Res, 1997,57(11):2124-2129.
  • 2[2]Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers[J]. Nat Genet, 1997,15(4):356-362.
  • 3[3]Li J, Yen C, Liaw D,et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer[J]. Science, 1997,275(5308):1943-1947.
  • 4[4]Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger,phosphatidylinositol 3,4,5-trisphosphate[J]. J Biol Chem,1998,273(22):13375-13378.
  • 5[5]Forgacs E, Biesterveld E J, Sekido Y, et al. Mutation analysis of the PTEN/MMAC1 gene in lung cancer[J]. Oncogene, 1998,17(12):1557-1565.
  • 6[6]Yaginuma Y, Yamashita J, Ishiya T, et al. Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers[J]. Mol Carcinog, 2000,27(2):110-116.
  • 7车艳辞,姚勤,戴淑真,罗兵,王言奎.子宫内膜癌和卵巢上皮性癌PTEN基因突变及其蛋白表达的意义[J].中华妇产科杂志,2002,37(10):608-611. 被引量:20
  • 8[8]Rubin MA, Gerstein A, Reid K, et al. 10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N +) versus lymph node-negative (pT2-3,N0) prostate cancer[J]. Hum Pathol, 2000,31(4):504-508.
  • 9[9]Yao YJ, Ping XL, Zhang H, et al. PTEN/MMAC1 mutations in hepatocellular carcinomas[J]. Oncogene, 1999,18(20):3181-3185.
  • 10[10]Yokomizo A,Tindall DJ,Drabkin H,et al. PTEN/MMAC1 mutations identified in small cell, but not in non-small lung cancers[J]. Oncogene, 1998,17(4)475-479.

二级参考文献6

  • 1Risinger JI,Hayes AK,Berchuck A,et al.PTEN MMAC1 mutations in endometrial cancers[].Cancer Research.1997
  • 2Yaginuma Y,Yamashita T,Ishiya T,et al.Abnormal structure and expression of PTEN MMAC1 gene in human uterine cancers[].Molecular Carcinogenesis.2000
  • 3Risinger JI,Hayes K,Maxwell GL,et al.PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics[].Clinical Cancer Research.1998
  • 4Tashiro H,Blazes MS,Wu R,et al.Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies[].Cancer Research.1997
  • 5Maxwell GL,Risinger JI,Tong B,et al.Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers[].Gynecologic Oncology.1998
  • 6Kurose K,Zhou XP,Araki T,et al.Frequent loss of PTENexpression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas[].American Journal of Pathology.2001

共引文献19

同被引文献18

  • 1Orita M, Iwahana H, Kanazawa H, et al. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms[J]. Proc Natl Acad Sci USA, 1989, 86(8):2766
  • 2Orita M, Suzuki Y, Sekiya T, et al. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction[J]. Genomics, 1989, 5(4):874
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  • 6Hayashi K, Yandell DW. How sensitive is PCR-SSCP[J]? Hum Mutat, 1993, 2(5):338
  • 7Maruya E, Saji H, Yokoyama S. PCR-LIS-SSCP (Low ionic strength single-stranded conformation polymorphism)--a simple method for high-resolution allele typing of HLA-DRB1, -DQB1, and -DPB1[J]. Genome Res, 1996, 6(1):51
  • 8Lynas C, Howe D. Simple, reliable detection of T cell clones by PCR-LIS-SSCP analysis of TCRgamma rearrangement[J]. Mol Cell Probes, 1998, 12(1):41
  • 9Abba MC, Gomez MA, Golijow CD. HLA-DQA1 allele typing by nonisotopic PCR-LIS-SSCP[J]. Braz J Med Biol Res, 2001, 34(7):867
  • 10Sambrook J, Fritsh EF, Maniatis T. Molecular Cloning: a laboratory manual[M]. 2nd Ed. New York, Cold Spring Harbor Laboratory Press, 1989, 382

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