儿茶酚氧位甲基转移酶基因G1947A多态性与吸烟行为相关性的Meta分析

Association of catechol-O-methyl transferase gene G1947A polymorphism with smoking behavior: a Meta-analysis

目的探讨儿茶酚氧位甲基转移酶(COMT)基因G1947A多态性与吸烟行为之间的关系。方法检索自建库至2018年11月Pub Med,EMBASE,Web of Science和Cochrane Library数据库,严格按照纳入和排除标准筛选文献。进行Meta分析计算组合效应值及其95%可信区间(CI)。进行亚组分析探讨性别和种族之间的差异。结果最终纳入文献16篇,其中包括7565名当前吸烟者、6 491名已经戒烟者、9 370名从未吸烟者、14 535名吸过烟者和16 140名当前不吸烟者。在显性模型中发现,COMT基因G1947A中的等位基因A可以降低总体人群吸过烟的风险(OR=0. 92,95%CI=0. 85～0. 98,P=0. 014),尤其是亚洲人群(OR=0. 77,95%CI=0. 62～0. 93,P=0. 025)。COMT基因G1947A多态性与目前是否吸烟和戒烟状态的关系在3种模型中均无显著差异(P> 0. 05)。敏感性分析、影响性分析对现有结果无实质影响,且没有检测到发表偏倚。结论 COMT基因G1947A中的A等位基因对总体人群初始不吸烟具有保护作用。

Objective To explore the relationship between catechol-O-methyl transferase(COMT)gene G1947A polymorphism and smoking behavior.Methods Relevant literature were searched in PubMed,EMBASE,Web of Science and Cochrane Library from inception up to Nov.2018.Data were strictly screened according to the inclusion and exclusion criteria.The combined effect values and the 95%confidence intervals(CI)were calculated based on Meta-analysis.The differences in gender and ethnicity were investigated with subgroup analysis.Results A total of 16 researches were included,with 7 565 current smokers,6 491 ex-smokers,9 370 never smokers,14 535 ever smokers and 16 140 nonsmokers involved.Significant effects of smoking initiation with COMT G1947A polymorphism were found in the dominant model(OR=0.92,95%CI=0.85-0.98,P=0.014),especially in Asians(OR=0.77,95%CI=0.62-0.93,P=0.025).The associations of COMT G1947A polymorphism with smoking persistence and cessation were not significant in the 3 models.After sensitivity and influence analyses,the pooled results did not change substantially.No publication bias was detected.Conclusion The A allele in COMT G1947A has a modest protective effect for smoking initiation.