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IL-4及其受体在哮喘中的作用 被引量:1

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摘要 支气管哮喘是由嗜酸粒细胞、肥大细胞和T淋巴细胞等多种炎性细胞参与的气道慢性炎症。是以TH2型细胞因子增高和气道高反应性为特征的变态反应性疾病。IL-4有刺激B细胞的增值和分化,促进IgE合成和肥大细胞的生长,促进T细胞向TH2型转化等作用。它需要与靶细胞上的IL-4R结合并产生信号,才能导致一系列激酶所介导的磷酸化反应,sIL-4R能在细胞外抑制IL-4的功能,可作为IL-4的拮抗剂发挥作用。
机构地区 北京电力医院
出处 《中国水电医学》 2008年第5期316-318,共3页
关键词 IL-4 IL-4R 哮喘
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参考文献10

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