摘要
目的分析药物不良反应(ADR)发生规律及特点,为临床合理用药及药物安全性评价提供依据。方法对收集到的478例ADR报告进行统计分析及评价。结果男性患者ADR发生比例较大;ADR多发生在50岁以上的老年患者;抗菌药物、心血管药物、中药制剂、血液及生物制剂发生ADR比率较大;临床表现以皮肤及附件损伤最为常见,其次为神经系统和胃肠道系统。结论应重视ADR监测,加强对医务人员ADR知识的培训和宣传,开展全方位的ADR监测工作,减少和避免ADR的发生。
Objectives Supply the evidence to clinic drug administrate and estimation of medicine safety dy analyzing the rule and characters of medicine adverse reaction.Methods Statistic analysis and estimate to 478 ADR reports collected.Results The probability of male suffer of ADR occurrence is great,old sufferers over 50 are easily occur ADR;the probability of antibacteria medicine,cardiac medicine,Chinese remedy,blood and biological products to occur ADR is great;clinic representation is mostly skin and accessories huet,next is nervous and digestive system.Conclusion Make much of ADR monitoring,strengthen training and obstruction for ADR knowledge to medical stuff,develop ADR monitoring,reduce and avoid ADR occurrence.
关键词
药物不良反应
监测
统计分析
adverse drug reaction monitor statical analysis
