摘要
角膜胶原交联术(CXL)利用紫外光A和感光剂核黄素,介导角膜基质内胶原纤维相互交联,提高角膜机械硬度和角膜基质的生物力学稳定性,从而阻止圆锥角膜等扩张性疾病的进展。近年来,经过临床研究发现,CXL对感染性角膜疾病的治疗也能取得良好的治疗效果,因此CXL成为了一种安全、有效的治疗感染性角膜疾病的新方法。综述该技术在治疗感染性角膜疾病方面的研究进展,回顾分析了该技术的基本原理,治疗感染性角膜疾病的作用机制、适应证、禁忌证、治疗技术的研究。
Corneal collagen crosslinking(CXL)using ultraviolet light(UVA)-riboflavin photochemistry increases corneal rigidity and improves biomechanical stability of the stroma,thereby limiting the progression of corneal expansion.In recent years,CXL has also been used as a safe and effective treatment for infectious corneal diseases.In this paper,we review the basic principles,indications,and contraindication of CXL for the treatment of infectious corneal disease.
作者
高芯(综述)
王旭(审校)
GAO Xin;WANG Xu(School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200,Shandong,China;Ocular Surface Department,Jinan Second People's Hospital,Jinan 250000,Shandong,China)
出处
《山东大学耳鼻喉眼学报》
CAS
2019年第5期153-157,共5页
Journal of Otolaryngology and Ophthalmology of Shandong University
关键词
角膜胶原交联术
感染性角膜疾病
适应证
禁忌证
Corneal collagen cross linking
Infectious corneal disease
Indications
Contraindication
