基于代谢组学技术研究老年原发性高血压肾气亏虚证本质的可行性探讨

Feasibility Study on Essence of Senile Essential Hypertension with Kidney-qi Deficiency Syndrome Based on Metabolomics

代谢组学作为后基因时代的新兴"组学",是一项对生物系统内所有代谢产物进行定性、定量分析的系统性研究技术。它所研究的代谢物是机体受到刺激干扰后整体功能状态的"生化表型",因此代谢组学具备系统、动态、整体、分析的特点,与中医学整体观、系统观以及辨证论治思想相契合。老年高血压是原发性高血压的临床亚型之一,具有特征性的发病机制和证候特点,肾气亏虚是其病理机制中的重要环节,代谢组学技术为其证候本质的探索开拓了一条新思路。分析代谢组学技术与中医证候本质研究的契合点,就代谢组学技术研究老年原发性高血压肾气亏虚证本质的可行性进行探讨。

As an emerging 'omics' in the post-genomic era,metabonomics is a systematic research technology for qualitative and quantitative analysis of all metabolites in a biological matrix.The metabolites studied by the organism are the 'biochemical phenotype' of the whole functional state after the body is disturbed by stimulation,so metabonomics has the characteristics of system, dynamics, entirety and analysis,which accord with the holistic view,the system view and the treatment according to syndrome differentiation theory of traditional Chinese medicine. Elderly hypertension is one of the clinical subtypes of hypertension,which has characteristic pathogenesis and syndrome characteristics,the kidney qi deficiency is a significant part of its pathology mechanisms,and metabonomics technology has opened up a new way to explore the essence of this syndrome. In this paper,the conjunction between metabonomics and the essence of TCM syndromes were analyzed,the feasibility of the research on the essence of elderly hypertension with kidney qi deficiency syndrome based on metabonomics technology was also discussed.