期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

信号转导和转录激活因子3与宫颈癌的关系研究进展 被引量：2

下载PDF
导出
摘要 宫颈癌是最常见的妇科恶性肿瘤,宫颈癌的早期诊断和治疗具有重要的临床意义,而如何阻止宫颈癌前病变向宫颈癌的恶性进展已成为近年来防治宫颈癌的研究热点。研究表明,信号转导和转录激活因子3(STAT3)在人乳头瘤病毒(HR-HPV)感染、宫颈癌前病变及宫颈癌的进展中发挥重要作用,将STAT3作为宫颈癌防治的新靶点具有重要的临床价值。
作者 张自辉 叶红 刘秀娟
机构地区 三峡大学第一临床医学院
出处 《山东医药》 CAS 北大核心 2015年第4期105-107,共3页 Shandong Medical Journal
基金 湖北省自然科学基金资助项目(2014CFB687) 湖北省教育厅科学技术研究项目(B2013176)
关键词 宫颈癌 信号转导和转录激活因子3 人乳头瘤病毒
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献18

  • 1Zheng Wei,Xian Jiang,Haiquan Qiao,Bo Zhai,Lianfeng Zhang,Qiang Zhang,Yuanhong Wu,Hongchi Jiang,Xueying Sun.STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells[J]. Cellular Signalling . 2013 (4)
  • 2Feifei Li,Wanhua Ren,Yanda Zhao.Downregulation of GRIM-19 is associated with hyperactivation of p-STAT3 in hepatocellular carcinoma. Medical Oncology . 2012
  • 3Hsueh Yi-Jen,Chen Hung-Chi,Chu Wing-Keung,Cheng Chien-Chia,Kuo Pei-Ching,Lin Liang-Yu,Ma Hui-Kang,Chen Jan-Kan.STAT3 regulates the proliferation and differentiation of rabbit limbal epithelial cells via a ΔNp63-dependent mechanism. Investigative Ophthalmology . 2011
  • 4Yu Hua,Pardoll Drew,Jove Richard.STATs in cancer inflammation and immunity: a leading role for STAT3. Nature reviews. Cancer . 2009
  • 5Okamoto Takashi,Inozume Takashi,Mitsui Hiroshi,Kanzaki Mirei,Harada Kazutoshi,Shibagaki Naotaka,Shimada Shinji.Overexpression of GRIM-19 in cancer cells suppresses STAT3-mediated signal transduction and cancer growth. Molecular Cancer . 2010
  • 6R. C. Sobti,Neha Singh,Showket Hussain,Vanita Suri,A. C. Bharti,B. C. Das.Overexpression of STAT3 in HPV-mediated cervical cancer in a North Indian population[J]. Molecular and Cellular Biochemistry . 2009 (1)
  • 7A. Furuhata,A. Kimura,K. Shide,K. Shimoda,M. Murakami,H. Ito,S. Gao,K. Yoshida,Y. Tagawa,K. Hagiwara,A. Takagi,T. Kojima,M. Suzuki,A. Abe,T. Naoe,T. Murate.p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation[J]. Biochemical and Biophysical Research Communications . 2009 (4)
  • 8Rabia Faridi,Amreen Zahra,Khalida Khan,Muhammad Idrees.Oncogenic potential of Human Papillomavirus (HPV) and its relation with cervical cancer. Virology Journal . 2011
  • 9Chel HunChoi,Sang YongSong,HeeseokKang,Yoo‐YoungLee,Chul‐JungKim,Jeong‐WonLee,Tae‐JoongKim,Byoung‐GieKim,Je‐HoLee,Duk‐SooBae.Prognostic significance of p‐STAT3 in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy[J]. Journal of Obstetrics and Gynaecology Research . 2010 (2)
  • 10Kana Wang,Bin Zhou,Jian Zhang,Yalan Xin,Ting Lai,Yanyun Wang,Qiannan Hou,Yaping Song,Yue Chen,Yi Quan,Mingrong Xi,Lin Zhang.Association of Signal Transducer and Activator of Transcription 3 Gene Polymorphisms with Cervical Cancer in Chinese Women. DNA and Cell Biology . 2011

二级参考文献29

  • 1韩安家,宗永生,何洁华,林素暇,梁英杰.STAT3在鼻咽癌中的表达特征及其与bcl-2和LMP1表达的关系[J].肿瘤防治杂志,2005,12(2):81-84. 被引量：12
  • 2朱青,张王刚,王立锋,王芳,张勇,杨安钢.Hsp701A基因的RNA干涉对HepG2细胞化疗敏感性的影响[J].细胞与分子免疫学杂志,2006,22(5):606-608. 被引量：3
  • 3范钰,张尤历,张宇川,吴莺,魏金文,程兆明,何亚龙,王银环,李华.siRNA敲除STAT3基因对结肠癌HCT116细胞侵袭的抑制[J].江苏大学学报（医学版）,2007,17(1):46-48. 被引量：8
  • 4Jove R. Preface: STAT signaling[J]. Oncogene, 2000, 19(21): 2466-2467.
  • 5Bromberg J F, Wrzeszczynska M H, Devgan G, et al. Stat3 as anoncogene[J]. Cell, 1999, 98(3):295-303.
  • 6Yu H, Jove R. The STATs of cancer--new molecular targets come of age[J]. Nat Rev Cancer, 2004, 4(2): 97- 105.
  • 7Niu G, Wright K L, Ma Y, et al. , Role of Star3 in regulating p53 expression and function[J]. Mol Cell Biol, 2005, 25(17): 7432-7440.
  • 8Gritsko T, Williams A, Turkson J, et al. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells [J].Clin Cancer Res, 2006, 12(1): 11-19.
  • 9Page C, Huang M, Jin X, et al. , Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells[J].Int J Oncol, 2000,17(1):23 -28.
  • 10Chen C L, Hsieh F C, Lieblein J C, et al. Star3 activation in hu man endometrial and cervical cancers[J]. Br J Cancer, 2007, 96(4) : 591-599.

共引文献10

同被引文献15

引证文献2

二级引证文献10

山东医药
2015年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部