肝细胞肝癌组织中CD_(90)表达变化及意义

Expression and clinical significance of CD_(90) in hepatocellular carcinoma

目的观察肝细胞肝癌(HCC)组织中肿瘤干细胞标记物CD90的表达变化,并探讨其临床意义。方法采用免疫组化法检测60例HCC组织(HCC组)、60例癌旁组织(癌旁组)及60例正常肝脏组织(对照组)中的CD90,分析其表达与HCC临床病理参数的关系。结果 CD90阳性表达率HCC组为76.7%(46/60)、癌旁组为48.3%(29/60)、对照组为0,3组组间两两比较,P均<0.01。CD90表达与HCC患者的性别、民族、有无门静脉瘤栓、包膜是否完整、TMN分期、病理分级有关(P均≤0.05),与HCC患者的年龄、肿瘤大小、甲胎蛋白高低、乙肝病毒是否阳性无关(P均>0.05)。结论 CD90在HCC组织及癌旁组织中高表达,HCC组织中表达更高;癌组织中CD90表达有助于HCC患者预后的判断,可为患者进行个体化诊断治疗提供参考。

Objective To explore the expression and clinical significance of CD90 in hepatocellular carcinoma. Methods The expression of CD90 in cancer tissues,para-carcinoma tissues and normal liver tissues were detected by immunohistochemical method,and to analyze the significance. Results The positive expression rate of CD90 was 76. 7%( 46 /60)in HCC group,48. 3%( 29 /60) in paraneoplastic group,0 in normal group; there were significant differences among three groups( all P < 0. 01). The expression of CD90 in HCC tissues was correlated with gender,ethnicity,portal vein tumor thrombus,envelope integrity,clinical and pathological staging( all P < 0. 05); which was not associated with age,tumor size,AFP values and the expression of hepatitis B( all P < 0. 05). Conclusion The expression of CD90 increased in cancer tissues and para-carcinoma tissues,especially in cancer tissues,which maight be closely related to a poor prognosis of patients with liver cancer.