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高强度聚焦超声局部消融辅助FOLFOX6方案治疗胃肠道肿瘤肝转移的效果观察 被引量:2

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摘要 目的观察高强度聚焦超声(HIFU)局部消融辅助FOLFOX6方案治疗胃肠道肿瘤肝转移的效果。方法选择胃肠道肿瘤肝转移患者80例,随机分为观察组、对照组各40例。观察组采用HIFU局部消融联合FOLFOX6方案化疗,对照组仅采用FOLFOX6方案化疗,共化疗8个周期。观察两组近期疗效、KPS评分、T细胞亚群、VAS、肝功能变化及不良反应。结果观察组有效率、疾病控制率均高于对照组(P均<0.05);两组治疗前后KPS评分比较差异均无统计学意义(P均>0.05);观察组治疗后1周较治疗前1周CD+4、CD+4/CD+8明显升高(P均<0.05),而对照组治疗后1周虽较治疗前1周有所升高,但差异无统计学意义(P均>0.05);随着化疗周期的增加,两组从第4周期开始疼痛程度明显减轻,但观察组疼痛减轻程度大于对照组(P均<0.05);两组治疗前后肝功能均无明显变化,且毒性反应多为Ⅰ、Ⅱ度,不影响继续治疗。结论 HIFU局部消融辅助FOLFOX6方案治疗胃肠道肿瘤肝转移效果较好,能提高患者免疫力,减轻疼痛程度,且不增加肝功能损害。
出处 《山东医药》 CAS 北大核心 2015年第13期58-60,共3页 Shandong Medical Journal
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参考文献12

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