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CXCL12-CXCR4/CXCR7信号轴相关疾病研究进展 被引量：16

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摘要 趋化因子CXCL12及其受体CXCR4、CXCR7在多种细胞和组织中广泛表达,对免疫系统、循环系统及中枢神经系统的发育起重要作用。现对CXCL12-CXCR4/CXCR7信号轴相关疾病(艾滋病、乳腺癌、前列腺癌、肺癌、胃癌、卵巢癌、急性白血病、胶质母细胞瘤、WHIM综合征、哮喘)的研究进展进行综述,认为在不同水平对CXCL12-CXCR4/CXCR7信号轴进行调节,可为以上相关疾病的治疗提供新的手段和策略。
作者 牛坤汀 莫碧文 王志霞 韦江红 黄剑伟 饶立宗 吕欣
机构地区 桂林医学院 桂林医学院附属医院
出处 《山东医药》 CAS 北大核心 2015年第17期89-91,共3页 Shandong Medical Journal
基金 国家自然科学基金资助项目(81260009) 广西壮族自治区自然科学基金重点项目(2012GXNSFDA053020)
关键词 趋化因子 CXC 受体 趋化因子 信号传导
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献17

  • 1Filippo Gagliardi,Ashwin Narayanan,Michele Reni,Alberto Franzin,Elena Mazza,Nicola Boari,Michele Bailo,Paola Zordan,Pietro Mortini.The role of CXCR4 in highly malignant human gliomas biology: Current knowledge and future directions[J]. Glia . 2014 (7)
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  • 3Guiyuan Chenl,Wei Wang,Shengke Mengl,Lichao Zhang,Wenxue Wangl,Zongmin Jiangl,Min Yul,Qinghua Cuil ML.CXC Chemokine CXCL12 and Its Receptor CXCR4 in Tree Shrews (Tupaia belangeri):Structure, Expression and Function. PLOS ONE . 2014
  • 4Hai-Feng Ou-Yang,Yun Huang,Xing-Bin Hu.Suppression of allergic airway inflammation in a mouse model of asthma by exogenous mesenchymal stem cells. Experimental Biology . 2011
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  • 7Shengwen Wang,Shanyi Zhang,Junliang Li,Xinke Xu,Yinlun Weng,Meiguang Zheng,Leping Ouyang,Fangcheng Li.CXCL12-induced upregulation of FOXM1 expression promotes human glioblastoma cell invasion[J]. Biochemical and Biophysical Research Communications . 2013
  • 8Katia Beider,Michal Begin,Michal Abraham,Hanna Wald,Ido D. Weiss,Ori Wald,Eli Pikarsky,Evelyne Zeira,Orly Eizenberg,Eithan Galun,Izhar Hardan,Dan Engelhard,Arnon Nagler,Amnon Peled.CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth[J]. Experimental Hematology . 2011 (3)
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二级参考文献13

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  • 9Nagase H, Miyamasu M, Yamaguchi M, et al. Expression of CXCR4 in eosinophils: functional analyses and cytokine-mediated regulation. J Immunol, 2000,164:5935-5943.
  • 10栾斌,黄先杰,乔俊英.SDF-1及CXCR4在哮喘小鼠肺组织中的表达及布地奈德的干预作用[J].中国当代儿科杂志,2010,12(3):215-218. 被引量：8

共引文献3

同被引文献141

引证文献16

二级引证文献57

山东医药
2015年 第17期

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