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血清热休克蛋白70及基质金属蛋白酶-9在肺癌中的水平变化及诊断价值

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摘要 目的探讨肺癌患者血清热休克蛋白70(HSP70)和基质金属蛋白酶-9(MMP-9)对肺癌的诊断价值及其与肺癌组织分型、临床分期、远处转移的关系。方法选择肺癌患者36例(肺癌组)(包括肺腺癌20例,肺鳞癌11例,小细胞肺癌5例)及同期查体健康者23例(对照组),采用ELISA法检测外周血MMP-9与HSP-70水平,绘制受试者工作特征(ROC)曲线评价两项指标诊断肺癌的特异度和敏感度,采用Pearson相关分析HSP70与MMP-9水平的关系。结果肺癌组血清HSP70、MMP-9水平高于对照组(P均<0.01);血清HSP70、MMP-9水平腺癌高于鳞癌、小细胞肺癌,有淋巴结转移高于无淋巴结转移,肿瘤最大直径≥3 cm高于<3 cm,Ⅲ~Ⅳ期高于Ⅰ~Ⅱ期(P均<0.05)。MMP-9 ROC曲线下面积=0.86,以6.39 ng/m L为截断值,MMP-9诊断肺癌的敏感度为0.889,特异度为0.522。HSP70 ROC曲线下面积=0.92,以64.82 pg/m L为截断值,HSP70诊断肺癌的敏感度为0.944,特异度为0.783。两者相关系数为0.864。HSP70与MMP-9在肺癌血清中表达呈明显正相关(r=0.864,P<0.01)。结论肺癌患者血清MMP-9、HSP70水平升高,其二者的检测对肺癌的诊断有重要价值。
作者 何丽杰
出处 《山东医药》 CAS 北大核心 2015年第25期52-53,共2页 Shandong Medical Journal
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参考文献8

  • 1Cynthia Jumper,Everardo Cobos,Charles Lox.Determination of the serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with either advanced small-cell lung cancer or non-small-cell lung cancer prior to treatment[J]. Respiratory Medicine . 2003 (2)
  • 2DM Parkin,F Bray,J Ferlay,P Pisani.Global cancer statistics, 2002. CA: a cancer journal for clinicians . 2005
  • 3Cox G,Jones J L,O’Byrne K J et al.Matrix metalloproteinase 9 and the epidermal growth factor signal pathway in operable non-small cell lung cancer. Clinical Cancer Research . 2000
  • 4Xu, Shoujiang,Liu, Yang,Wang, Taihong,Li, Jinghong.Positive potential operation of a cathodic electrogenerated chemiluminescence immunosensor based on luminol and graphene for cancer biomarker detection. Analytical Biochemistry . 2011
  • 5Stetler-Stevenson WG,Liotta LA,Kleiner DE Jr,et al.Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. The FASEB Journal . 1993
  • 6Sugio Kenji,Sugaya Masakazu,Hanagiri Takeshi,Yasumoto Kosei.[Tumor marker in primary lung cancer]. Journal of UOEH . 2004
  • 7J. Berger,E. Laack,W. Fiedler,A. K?hler,C. Kugler,D.K. Hossfeld,T. Dierlamm,C. Knuffmann,G. Vohwinkel,A. Niestroy,N. Dahlmann,A. Peters.Pretreatment serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in non-small-cell lung cancer. Annals of Oncology . 2002
  • 8Atkinson JM,Pennington CJ,Martin SW,et al.Expression of matrix metalloproteinase 7 and 9 in non-small cell lung cancer. Cancer . 2007

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