幽门螺杆菌感染与胃息肉关系的Meta分析

Association between Helicobacter pylori infection and gastric polyps: a meta-analysis

目的分析幽门螺杆菌(Hp)感染与胃息肉的相关性。方法检索从建库至2015年4月Pub Med、Embase、中国生物医学文献数据库、中国知网、万方期刊数据库、维普数据库内收录的Hp感染与胃息肉关系的病例对照研究。由两位研究者按照纳入与排除标准筛选文献,提取资料和评价纳入研究质量后,采用Rev Man5.3及STATA11.0软件进行Meta分析。结果共纳入12个病例对照研究,总样本量4 453例,其中胃息肉组2 009例、对照组2 444例。Meta分析结果显示,胃息肉组Hp感染率与对照组相比差异无统计学意义(OR=0.86,95%CI:0.44~1.66,P=0.650);胃底腺息肉患者Hp阳性率与对照组相比差异有统计学意义(OR=0.32,95%CI:0.15~0.68,P=0.004)。敏感性分析显示结果较为稳定。结论当前证据不足以证明Hp感染与胃息肉有关。

Objective To systematically evaluate the association between Helicobacter pylori ( Hp) infection and gas-tric polyps.Methods We searched PubMed, Embase, CBM, CNKI, Wan-fang data and VIP Data from inception to A-pril, 2015, to collect case-control studies concerning the association between Hp and gastric polyps .Two reviewers inde-pendently screened literatures according to the inclusion and exclusion criteria , extracted data and assessed the methodolog-ical quality of included studies; and then, meta-analysis was performed using the RevMan 5.3 software and STATA11.0 software.Results Twelve case-control studies were included , a total of 4 453 cases, 2 009 cases were in the gastric pol-yps group and 2 444 cases were in the control group .The results of meta-analysis showed that: there were no significant differences in the Hp infection rate between the gastric polyps group and the control group (OR=0.86, 95%CI:0.44-1.66, P=0.65);there were significant differences in the Hp positive rate between the fundic gland polyps and the control group (OR=0.32, 95%CI:0.15-0.68, P=0.004).Sensitivity analysis showed the results were stable .Conclusion The current evidence is insufficient to prove that there is an association between Hp infection and gastric polyps .