后循环缺血性眩晕痰湿证不同兼证之间超敏C反应蛋白及纤维蛋白原水平比较研究

Comparison Study of Hypersensitive C-reactive Protein And Fibrinogen among Accompanying Syndromes of Phlegm Dampness Syndrome of Patients with Posterior Circulation Ischemic Vertigo

目的:比较后循环缺血性眩晕痰湿证不同兼证之间血浆超敏C反应蛋白和纤维蛋白原水平。方法:选择2016年6月至2017年7月96例后循环缺血性眩晕住院患者,其中痰湿兼肝火证32例,痰湿兼血瘀证31例,痰湿兼脾虚证33例;另选择门诊健康志愿者10例。测体质量指数,检测血生化指标及超敏C反应蛋白和纤维蛋白原。结果:后循环缺血性眩晕三组之间,痰湿兼血瘀证低密度脂蛋白胆固醇高于痰湿兼肝火证(P<0.05)。各组之间体质量指数、血尿酸、胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、空腹血糖相比,差异无统计学意义(P> 0.05)。痰湿兼血瘀证、痰湿兼脾虚证两组超敏C反应蛋白均高于对照组(P<0.01,P<0.05),痰湿兼血瘀证组超敏C反应蛋白明显高于痰湿兼肝火证(P<0.01)。痰湿兼血瘀证、痰湿兼脾虚证纤维蛋白原均明显高于对照组(P<0.01)和痰湿兼肝火证(P<0.01),痰湿兼血瘀证纤维蛋白原明显高于痰湿兼脾虚证(P<0.01)。结论:后循环缺血性眩晕痰湿兼血瘀证、痰湿兼脾虚证超敏C反应蛋白、纤维蛋白原均有不同程度的升高,而痰湿兼血瘀证升高尤为明显,可为中医辨证提供一定的依据。

Objective:To compare the plasma levels of hypersensitive C-reactive protein and fibrinogen among accompanying syndromes of phlegm dampness syndrome of patients with posterior circulation ischemic vertigo. Methods:Ninety-six hospitalized patients with posterior circulation ischemic vertigo from June 2016 to July 2017 were selected as the research objects,including 32 patients with phlegm dampness and liver fire syndrome,31 patients with phlegm dampness and blood stasis syndrome and 33 patients with phlegm dampness and spleen deficiency syndrome.Another 10 healthy volunteers were also selected as the research objects. Body mass index,blood biochemical parameters,hypersensitive C-reactive protein and fibrinogen were measured. Results:Among the three groups of posterior circulation ischemic vertigo,the low density lipoprotein cholesterol level of the phlegm dampness and blood stasis syndrome group was higher than those of the phlegm dampness and liver-fire syndrome group(P<0.05). There was no stasticas significance difference in levels of body mass index,serum uric acid,cholesterol,triglyceride,low density lipoprotein cholesterol,high density lipoprotein cholesterol and fasting blood glucose among all the groups(P> 0.05). The hypersensitive C-reactive protein level of the phlegm dampness and blood stasis syndrome group,phlegm dampness and spleen deficiency syndrome group was higher than that of the control group(P<0.01,P<0.05). The hypersensitive C-reactive protein level pf the phlegm dampness and blood stasis syndrome group was significantly higher than that of the phlegm dampness and liver fire syndrome group(P<0.01). The fibrinogen level of phlegm dampness and blood stasis syndrome group and phlegm dampness and spleen deficiency syndrome group were significantly higher than that of the control group(P<0.01)and phlegm dampness and liver fire syndrome group(P<0.01). The fibrinogen level of the phlegm dampness and blood stasis syndrome group was significantly higher than that in the phlegm dampness and spleen deficiency syndrome group(P <0.01). Conclusions :In patients with posterior circulation ischemic vertigo of phlegm dampness and blood stasis syndrome,phlegm dampness and spleen deficiency syndrome,the hypersensitive C-reactive protein level and fibrinogen level increase in varying degrees,especially in patients with phlegm dampness and blood stasis syndrome,which can provide some basis for syndrome differentiation of traditional Chinese Medicine.