生物蛋白胶在消化道隆起性病变切除术后的应用

Effect of Fibrin Glue on Patients after High Frequency Electrocoagulatomy for Gastrointestinal Protuberant Lesions

目的 :观察消化道隆起性病变切除术后应用国产医用生物蛋白胶 (FG)对电凝创面愈合及预防出血、穿孔的作用。方法 :6 5例隆起性病变均采用高频电凝切除术 ,术后随机分为 2组 :31例切除术后创面喷洒FG ;35例不作特殊处理。 2周内观察胸骨后、腹部疼痛及有无出血、穿孔并发症。结果 :FG组溃疡创面愈合率为 96 .77% ,对照组为 76 .4 1% (P <0 .0 1) ;FG组 1周内有疼痛者 5例 ,对照组为 19例。两组差异有显著性 (P <0 .0 1) ;治疗组 1周内出血 0例 ,而对照组有 6例 ,两者差异有显著性 (P <0 .0 1)。结论 :FG能有效预防消化道隆起性病变切除术后电凝创面的出血和穿孔 ,并能加速创面的愈合。

Objective: To compare postoperative lesion healing, bleeding prophylaxis of fibrin glue(FG) after high frequency electrocoagulatomy for gastrointestinal protuberant lesion. Methods: 65 patients with gastrointestinal protuberant lesions were divided into two groups randomly after high frequency electrocoagulatomy. 31 patients used FG with endoscopy (FG group)while the other 34 patients did not(control group). Complications such as poststernal and epigastric pain, bleeding, perforation were noted. Results: Lesion healing rate in therapy group was higher than that in control group(96.77 vs 76.41, P<0.01), with less frequency of postoperative pain (5/31 vs 19/34, P<0.01) and bleeding (0/31 vs 6/34, P<0.01) within a week in FG group. Conclusion: FG prescription should be a routine therapy after high frequency electrocoagulatomy for gastrointestinal protuberant lesions.