尿激酶-肝素溶栓治疗不稳定型心绞痛

Urokinase-Heparin Thrombolysis Therapy of Unstable Angina

目的 :比较尿激酶 (UK) 肝素溶栓与传统方法对不稳定型心绞痛 (UA)各自的疗效 ,探讨尿激酶溶栓治疗UA的合理方案。方法 :入选UA患者 92例 ,采用随机分组 ,分为溶栓组和对照组各 4 6例。观察两组治疗后近期及远期心绞痛的发生频度、程度、心电图改变及再住院率和转化为稳定型心绞痛的几率。结果 :溶栓组HR、BP等生命体征无改变 ,心肌耗氧量不增加 (P均 >0 .0 5 ) ,但是明显减少心绞痛发作的次数、缩短发作持续时间、减轻发作程度、降低S T段下移的幅度 (P <0 .0 5或P <0 .0 1) ,减少心绞痛发作时伴随的室性早搏、心动过速以及再住院的几率等 ,显示溶栓治疗抗心绞痛作用明显优于对照组。结论 :低剂量缓给UK加肝素维持的溶栓方案适用于治疗不稳定型心绞痛。

Objective: To compare the treatment effects between urokinase (UK) heparin thrombolytic and conventional therapy on unstable angina (UA), and to probe reasonable UA treatment program by use of UK. Methods: Adopting randomly, UA patients were divided into thrombolytic group (TG) and control group (CG); Forward and recent UA occurrence rate, ST T alteration of both groups, and the chances of re hospitalization and of turning into stable angina were studied. Results: 92 UA patients were selected, each group had 46 cases. The results indicated there were no changes of HR, BP and other vital sighs and no extra cardiac oxygen uptake in TG, but its anti angina effects were obviously better than CG in terms of lessening occurrence times and shortening lasting time of angina pectoris, alleviating suffering, lowering ST segment (P<0.05 or P<0.01), reducing the chances of accompanying ventricular premature beat, tachycardias and re hospitalization. Conclusion: The thrombolytic method of low dosage and slow infusion of UK combining with heparin fited for UA treatment.