PTEN在原发性乳腺癌中的表达和临床意义

Expression and Clinic signification of tumor suppressor gene PTEN in Primary breast carcinoma

目的 :研究抑癌基因PTEN在原发性乳腺癌组织中的表达及意义。方法 :应用免疫组织化学S -P法 ,检测了 5例正常乳腺组织、14例乳腺增生病 (不伴非典型增生 )组织和 40例乳腺癌中PTEN蛋白的表达。结果 :5例正常乳腺组织、14例乳腺增生病组织中均有PTEN蛋白的表达。 40例乳腺癌组织中 ,PTEN蛋白阳性表达 2 8例 ( 70 % ) ,表达强度与乳腺癌分化程度有关 (P <0 .0 0 1)。分化越差 ,PTEN蛋白表达越弱。结论 :乳腺癌组织中有抑癌基因PTEN的表达缺失 ,其异常表达可能与乳腺癌的发生。

Objective To investigate the Expres si on and Signification of tumor suppressor gene PTEN in Primary breast carcinoma t issues. Methods To detect expression of PTEN protein in 40 cases of primary breast carcinoma and 14 cases of mammary dysplasia without aty pia hyperplasia and 5 cases of normal mammary tissues by immunohistochemical SP method.Results the results showed that PTEN protein was ex pressed in all 5 cases of normal tissues and 14 cases of mammary dysplasia. But in 40 cases of breast carcinoma, only 28 cases were positive (70%). The intensit y of PTEN protein was association with differentiation degree of breast carcinom a (P<0.001). The poorer differentiation of carcinoma, the weaker expression of PTEN protein. Conclusion It showed that tumor suppresso r PTEN gene was abnormally expression in primary breast carcinoma. And PTEN is p robably related to carcinogenesis and development of primary breast carcinoma.