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人乳头瘤状病毒(HPV)感染与抑癌基因p16突变在食管鳞癌中相关研究进展

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摘要 食管癌是一种恶性程度较高、死亡率较高的消化道恶性肿瘤,在我国癌症发病率中居第四位,以食管鳞状细胞癌多见。早期多无明显特异性症状,常被忽视,一旦出现相关症状,如吞咽困难、吞咽痛、胸骨后疼痛、声音嘶哑、体重下降等,多为中晚期,预后较差。因此针对其病因进行预防成为当前研究的重点。食管癌的发病机制尚未完全明确,针对其病因学研究,目前已证实其发生是一个涉及多因素,多步骤的长期过程。年龄、
作者 容宇 刘俊峰
出处 《食管外科电子杂志》 2014年第1期20-25,共6页 Journal of Esophageal Surgery(Electronic Version)
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参考文献15

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二级参考文献16

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