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肝癌患者粘附分子和细胞因子的变化及其意义 被引量:1

The Changes and Significance of Adhesion Molecules in Periheral Blood with Hepatocarcinoma Patients
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摘要 目的 :观察肝癌患者外周血清可溶性P -选择素 (solubleP -selectin,CD6 2P) ,细胞间粘附分子 - 1(solubleintercellularadhesionmolecule - 1,sICAM - 1,CD5 4 ) ,血管细胞粘附分子 (solublevascularcelladhesionmolecule - 1,sVCAM - 1,CD10 6 )和白细胞粘附分子 β2整合素 (β2 -integrin ,CD18)的变化 ,并探讨其临床意义。方法 :采用流式细胞仪技术检测了 4 8例不同期肝癌患者外周血清sP -selectin ,sICAM - 1sVCAM - 1水平和白细胞CD18的表达。结果 :与正常对照组相比 ,血清sP -selectin ,sICAM - 1sVCAM - 1水平和白细胞CD18的表达显著增加。结论 :肝癌患者外周血清sP -selectin ,sICAM - 1sVCAM - Objective:To investigated the changes and significances of adhesion molecules in periheral blood with hepatocarcinoma patients.Method:the level of serum soluble P-selectin(sP-selectin),intercellular adhesion molecule-1(sICAM-1)and vascular cell adhesion molecule-1(sVCAM-1),and the expression of β 2-integrin(CD18)on neutropnils were determined using flow cytometry in 48 cases of hepatocarcinoma and 30 normal volunteers controls.Results:The mean fluorescence intensity of sP-selectin,sICAM-1,sVCAM-1 and CD18 were significantly higher in all subgroups of patients with hepatocarcinoma than in the control( P <0 05).Conclusions:Serum P-selectin,ICAM-1 and VCAM-1 levels and the CD18 expression on neutrophils were claimed to be the valuable markers in the early clinical staging in diagnosis.
出处 《华西医学》 CAS 2003年第3期304-305,共2页 West China Medical Journal
基金 国家自然科学基金项目 (39680 0 30 )
关键词 肝癌 粘附分子 细胞因子 P一选择素 Hepatocarcinoma sP-selectin sICAM-1 VCAM-1sICAM-1 CD18
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