^(13)N-NH_3PET脑血流灌注显像早期诊断缺血性脑梗死的研究

The Preliminary Report of ^(13)N-ammonia PET Scan in Incipient Diagnosis of Acute Cerebral Infarction

目的 探讨氮 - 13-氨水 ( 13 N -NH3 )脑血流灌注显像在早期缺血性脑梗死的诊断价值 .方法 对 5例缺血性脑梗死、10例对照组 (无脑血管病史的成年人 ) ,在首次CT检查后 1小时内静脉注射13 NH3 · 74 0～ 92 5MBq ,3分钟后 ,行T +E三维方式脑血流灌注显像 .图象分析采用视图分析及镜像比值法测量左 /右侧相应脑区SUV比值 (SU Vr) .结果 对照组左 /右脑区SUVr为 1.0± 0 .1.脑梗死组SUVr均 <0 .7(比值介于 0 .33～ 0 .6 9,平均 0 .5 1) . 5例缺血性脑梗死患者共发现病灶 12个 ,明显多于其他影像手段所检出病灶数 .结论 13 N -NH3 PET显像作为一种灵敏度高、定位准确且安全的功能影像学检查手段值得在临床中进行推广 ,对缺血性脑梗死的早期诊断具有重要临床价值 .

Objective To evaluate the diagnostic value of 13 N-NH 3 PET in acute ischemic cerebrovascular disease. Methods Following CT scans, 5 acute cerebral infarction patients were performed with 13 N-NH 3 PET brain perfusion images within 4-11 hours of the onset. The scans were began in 3 minutes after the injection with 740-925 MBq radiotracer. The PET images were analysed by visual and semiquanlitative methods. The standard uptake value (SUV) was measured on both of lesions and its mirror side of the brain. Results The symmetric brain uptake were found in 10 normal controls with 1.00± 0.12 of left to right ratio.T/N SUV ratio were less than 0.7 (0.33～0.69,average0.51)in all acute cerebral infarction patients . 12 radioactive defects were seen on the PET scans and first CT scans only found 3 of them. Conclusions The results show that 13 N-ammonia PET scan has significant clinical value in the diagnosis of cerebral infarction in very early phase.