上海社区中老年人群代谢综合征与心血管疾病患病风险相关性研究

Study on the association between metabolic syndrome and risk of cardiovascular disease in middle-aged and elderly community-dwelling residents in Shanghai

目的·分析上海社区40岁及以上居民代谢综合征(MS)及其组分与心血管疾病(CVD)患病风险的相关性。方法·采用整群抽样的方法,选取上海宝山区淞南社区40岁及以上的常住居民10 185人,针对相关病史进行问卷调查,并完成人体指标测量及相关实验室检查。结果·研究人群MS患病率为30.99%,女性患病率显著高于男性(35.34%vs 24.40%),且随着年龄增长MS患病率显著增加。CVD患病率为5.97%,其中男性患病率显著高于女性(7.45%vs 4.99%)。Logistic回归分析显示,在校正年龄、体重指数、吸烟、饮酒状态、运动量及教育水平后,男性MS患者CVD患病风险增加0.46倍(OR为1.46,95%CI为1.11~1.92),女性MS患者CVD患病风险增加0.34倍(OR为1.34,95%CI为1.03~1.74)。在MS各组分中,中心性肥胖、血压升高及高血糖均能增加男性CVD患病风险,而高三酰甘油、高血糖则能显著增加女性CVD患病风险。结论·淞南社区40岁及以上人群约1/3患有MS,MS及其组分能显著增加CVD的患病风险。

Objective·To investigate the association between metabolic syndrome(MS) and risk of cardiovascular disease(CVD) in community-dwelling residents ≥ 40 years of age in Shanghai.Methods·The cross-sectional study was conducted in 10 185 residents aged≥40 years selected by cluster sampling from Songnan community of Baoshan District.The questionnaire was used to collect relevant medical history.Anthropometry and biochemistry measurements were also performed.Results·The prevalences of MS and CVD in study population were 30.99% and 5.97%,respectively.The prevalence of MS was significantly higher in females than in males(35.34% vs24.40%) and increased with age.The prevalence of CVD was significantly higher in males than in females(7.45% vs 4.99%).Logistic regression analysis indicated that MS was associated with an increased risk of CVD in males(OR 1.46,95% CI 1.11-1.92)and in females(OR 1.34,95% CI 1.03-1.74) after adjustment for covariates including age,body mass index,smoking,drinking,exercise,and education level.Elevated blood pressure,high fasting glucose,and abdominal obesity were associated with increased risk of CVD in males with MS,while high triacylglycerol level and high fasting glucose were associated with increased risk of CVD in females.Conclusion·About one third of the residents aged ≥40 years in Songnan community had MS.MS and its components were significantly associated with increased risk of CVD.