肝干细胞和精原干细胞在肝脏疾病治疗中的应用

Application of hepatic stem cells and spermatogonial stem cells in treatment of liver disease

供体肝脏和肝细胞的严重短缺是限制其治疗肝脏疾病的最大难题。肝外组织来源的干细胞可作为肝细胞的重要来源,为肝病的治疗带来新的希望。该文根据国内外研究动态,并结合自己的研究综述了肝干细胞、精原干细胞及其他干细胞在肝脏疾病治疗中的研究进展,并展望了其未来的研究方向。

Severe shortage of liver donors and hepatocytes has become a major handicap for the treatment of liver disease.Extra-liver tissues and stem cells can provide an essential source of hepatocytes,which brings new promise for treating liver-related disease.Here we address the advances on the potential application of hepatic stem cells,spermatogonial stem cells,and other stem cells in the treatment of liver disease and future research directions based on studies from home and abroad,as well as our research.