生命早期肠道菌群的影响因素与儿童肥胖

Factors influencing gut microbiota in early life and childhood obesity

越来越多的证据显示,肠道菌群可能与肥胖的发生相关。生命早期是婴儿肠道菌群定植和菌群形成的关键时期,母亲产道菌群和母乳菌群是婴儿肠道菌群的重要来源。生命早期影响婴幼儿肠道定植菌群和菌群形成的主要因素包括宫内菌群暴露、分娩方式、喂养方式、抗生素使用、婴幼儿行为习惯、地理环境和遗传因素等。这些因素可能通过改变肠道菌群组成而影响儿童肥胖的发生风险。

Accumulating evidences suggest that gut microbiota is associated with the development of obesity.Early life is a critical period for gut microbial colonization and development.Maternal vaginal flora and breast milk microbiota are important microbial sources for infant gut microbiota.In early life,the factors that influence the colonization and composition of gut microbiota include intrauterine microbial exposure,mode of delivery,type of infant feeding,antibiotic use,infant behavior and habits,geographical environment,and child genetic factors,etc.These factors may influence the development of childhood obesity via changing the composition of intestinal microbiota.