期刊文献+

细胞程序性死亡与糖尿病肾病发病机制研究进展 被引量:3

Progress of research on the role of programmed cell death in the pathogenesis of diabetic nephropathy
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摘要 糖尿病肾病是糖尿病常见微血管病变,其发病机制并不完全清楚,研究发现细胞程序性死亡与糖尿病肾病发病机制关系密切,包括内质网应激、线粒体功能异常、糖基化产物毒性、糖原合酶激酶GSK3等机制均认为与糖尿病肾病细胞程序性死亡相关,表现为自噬功能障碍,肾脏固有细胞凋亡增加以及出现某些潜在的新型细胞程序性死亡过程。本综述结合目前国内外研究现状,对这一领域做一总结。 Diabetic nephropathy (DN)is a common microvascular complication of diabetes,and its pathogenesis is not entirely clear yet.It has been reported that programmed cell death (PCD)is closely associated with the pathogenesis of DN through pathways including endoplasmic reticulum stress, mitochondrial dysfunction,glycosylation products toxicity,and glycogen synthase kinase GSK3,which can lead to autophagy dysfunction,apoptosis increase of renal inherent cells,and PCD of some potential new types of cells.This review summarized the current domestic and international research data of this field.
作者 吴蔚桦
出处 《中华肾病研究电子杂志》 2015年第4期212-214,共3页 Chinese Journal of Kidney Disease Investigation(Electronic Edition)
基金 国家自然科学基金(81200533) 泸州医学院科研基金(2013ZRQN018 2014ZD-015)
关键词 细胞程序性死亡 糖尿病肾病 发病机制 Programmed cell death Diabetic nephropathy Pathogenesis
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参考文献1

  • 1LU ChengRong1SHI Ying1LUO Yuan1,DUAN LianNing1,HOU Yong2,HU HongBo3,WANG Zhe1 & XIANG PeiDe1 1Aviation Medicine Research Laborabory,General Hospital of Air Force,Beijing 100142,China,2 Department of Pharmacology,Hebei North University,Zhangjiakou 075000,China,3 Nutrition and Food Safety Center,College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China.MAPKs and Mst1/Caspase-3 pathways contribute to H2B phosphorylation during UVB-induced apoptosis[J].Science China(Life Sciences),2010,53(6):663-668. 被引量:3

二级参考文献24

  • 1Ahn S H,Cheung W L,Hsu J Y, et al.Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae. Cell . 2005
  • 2Lu C,Shi Y,Wang Z, et al.Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway. FEBS Letters . 2008
  • 3Arimoto K,Fukuda H,Imajoh-Ohmi S, et al.Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways. Nature Cell Biology . 2008
  • 4Bi W,Xiao L,Jia Y, et al.c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82. Journal of Biological Chemistry . 2010
  • 5Kam PCA,Ferch NI.Apoptosis: mechanisms and clinical implications. Anaesthesia . 2000
  • 6Ward IM,Chen J.Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. Journal of Biological Chemistry . 2001
  • 7Lu C,Li Y,Zhao Y,et al.Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. FASEB Journal, The . 2002
  • 8Tournier C,Hess P,Yang DD,et al.Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science . 2000
  • 9Sethi G,Sodhi A.Activation of c - Jun N - terminal kinase is required for ultraviolet B - induced apoptosis of murine peritoneal macrophages in vitro. J Photochemistry and Photobiology B: Biology . 2004
  • 10Shimizu H,Banno Y,Sumi N,et al.Activation of p38 mitogen-activated protein kinase and caspases in UVB-induced apoptosis of human keratinocyte HaCaT cells. Journal of Investigative Dermatology . 1999

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