摘要
糖尿病肾病是糖尿病常见微血管病变,其发病机制并不完全清楚,研究发现细胞程序性死亡与糖尿病肾病发病机制关系密切,包括内质网应激、线粒体功能异常、糖基化产物毒性、糖原合酶激酶GSK3等机制均认为与糖尿病肾病细胞程序性死亡相关,表现为自噬功能障碍,肾脏固有细胞凋亡增加以及出现某些潜在的新型细胞程序性死亡过程。本综述结合目前国内外研究现状,对这一领域做一总结。
Diabetic nephropathy (DN)is a common microvascular complication of diabetes,and its pathogenesis is not entirely clear yet.It has been reported that programmed cell death (PCD)is closely associated with the pathogenesis of DN through pathways including endoplasmic reticulum stress, mitochondrial dysfunction,glycosylation products toxicity,and glycogen synthase kinase GSK3,which can lead to autophagy dysfunction,apoptosis increase of renal inherent cells,and PCD of some potential new types of cells.This review summarized the current domestic and international research data of this field.
出处
《中华肾病研究电子杂志》
2015年第4期212-214,共3页
Chinese Journal of Kidney Disease Investigation(Electronic Edition)
基金
国家自然科学基金(81200533)
泸州医学院科研基金(2013ZRQN018
2014ZD-015)