细胞间线粒体转运的研究进展

Research Progress on Mitochondrial Transfer Between Cells

线粒体是真核生物能量代谢的重要细胞器,是细胞进行氧化磷酸化生成ATP的主要场所.他参与完成细胞能量代谢、维持离子浓度梯度、传递细胞凋亡信号等生理功能.阿尔茨海默病、帕金森病、心肌梗塞等疾病与线粒体功能异常相关.近年来发现,由创伤或炎症造成脑、心脏、肺缺氧时在细胞间会发生线粒体转移.线粒体转移,作为一种进化上保守的现象可能与神经降解、心血管疾病等相关.

Mitochondria are important organelles for eukaryotic energy metabolism and are the main sites for oxidative phosphorylation of cells to produce ATP. It participates in the physiological functions of cell energy metabolism, maintaining ion concentration gradient, and transmitting apoptosis signals. Diseases such as Alzheimer disease, Parkinson disease, and myocardial infarction are associated with mitochondrial dysfunction.In recent years, it has been found that mitochondrial transfer occurs between cells in the brain, heart, and lung during hypoxia caused by trauma or inflammation. Intercellular mitochondrial transfer, as an evolutionarily conserved phenomenon, may be associated with neurodegradation, cardiovascular disease, and the like.