lncRNA选择性剪接调控的研究进展

Advances in Research on Alternative Splicing Regulation of LncRNA

长链非编码RNA (lncRNA)选择性剪接是指剪除未成熟lncRNA中的内含子,并将外显子连接起来生成成熟lncRNA的过程.在各类疾病发生和发展过程中,异常的选择性剪接起着重要作用. lncRNA选择性剪接直接参与膀胱癌、结直肠癌、肝癌、神经母细胞瘤等多种肿瘤的发病机制,且与胚胎发育、软骨毛发发育、多系统萎缩症等紧密相关.在此,我们对lncRNA选择性剪接的起因、调控机制以及对疾病影响的研究进展进行综述.此外,本文还介绍了两个与lncRNA选择性剪接相关的数据库(SpliceMap和LNCediting).

lncRNA alternative splicing refers to the process of cleavage of introns in immature lncRNA and ligation of exons to generate mature lncRNA. Abnormal alternative splicing plays an important role in the development and progression of various diseases. lncRNA alternative splicing is directly involved in the pathogenesis of bladder cancer, colorectal cancer, liver cancer, neuroblastoma, and other tumors, as well as embryonic development, cartilage hair development, and multiple system atrophy. Here, we reviewed the causes,regulatory mechanisms, and research advances in the effects of lncRNA alternative splicing. In addition, two databases related to lncRNA alternative splicing(SpliceMap and LNCediting) are described.