免疫微环境对肿瘤干细胞影响研究进展

The Effects of Immune Microenvironment on Cancer Stem Cells

肿瘤干细胞是肿瘤组织中一小群特殊的未分化的细胞,由于其对化疗药耐受及致瘤潜能,被认为是造成肿瘤发生、复发和转移的根源,所以深入了解肿瘤干细胞特性对提高肿瘤治疗效率有着重要临床意义.肿瘤微环境中的免疫细胞及其分泌的分子与肿瘤干细胞之间存在复杂的相互作用,可以维持肿瘤干细胞的干性及自我更新能力.目前,肿瘤免疫微环境对肿瘤干细胞的影响、肿瘤干细胞对免疫微环境的塑造作用以及靶向肿瘤干细胞或免疫微环境等研究,是肿瘤干细胞研究领域的热点问题.本文就免疫微环境对肿瘤干细胞的影响、靶向肿瘤干细胞及微环境治疗的研究进展进行了综述.

Cancer stem cells(CSCs)are a small group of special undifferentiated cells in tumor tissues.Because of the drug tolerance and tumorigenic potential,CSCs are considered to be the source of tumor occurrence,recurrence and metastasis.Therefore,it is very significant to understand the characteristics of CSCs in augmenting clinical therapeutic efficiency.In tumor microenvironment the complex crosstalk between immune cells and CSCs sustains the stemness and self-renewal ability of CSCs.The effect of immune microenvironment on CSCs,the role of CSCs in shaping immune microenvironment,and the targeted therapy of CSCs or immune microenvironment are hot topics in this field.In this review,the effects of immune microenvironment on the characteristics of CSCs and the research progress of targeting CSCs and microenvironment are summarized.