基因工程功能化丝蛋白生物材料及其在生物医学中的应用

Functionalized genetic engineered silk-based biomaterials and their applications

丝蛋白生物材料具有优异的力学性能、良好的生物相容性及可降解性,在生物医学领域具有巨大的应用潜力。现有丝蛋白生物材料在结构和功能方面的相关知识,为设计合成新型丝蛋白生物材料提供了理论基础。此外,利用基因工程技术可将编码新肽或结构域的基因序列添加到编码丝蛋白的基因序列中,以获得具有新功能的丝蛋白生物材料,并更好地满足现代生物医学的需求。文中总结了基因工程功能化的丝蛋白生物材料在生物医学领域中的应用现状和发展前景。

Silk-based biomaterials are featured with excellent mechanical properties,good biocompatibility and biodegradability,which contribute to their potential applications in biomedical field.The current recognition of silk protein materials in structure and function provides a basic theory for the transformation of silk protein into new types of biomaterials.In addition,exogenous sequences encoding new peptide or structural domain can be inserted into the maternal gene sequences encoding silk proteins through genetic engineering technology to synthesize novel silk-based biomaterials with unique functions.This review summarizes the current trend and development perspective of genetically engineered functional silk-based materials for biomedical applications.