腺苷酸活化蛋白激酶在糖脂代谢调控中的研究进展

Research progress of Adenosine 5’-monophosphate-activated protein kinase in the regulation of glycolipid metabolism

AMP激活的蛋白激酶(AMP-activated protein kinase,AMPK)是一种异源三聚体复合物,作为机体能量平衡和糖脂代谢的重要激酶参与多种生理过程的调节。研究表明,炎症、糖尿病和癌症等多种慢性疾病也与AMPK功能和活性调节有密切关系。新近发现,糖尿病一线用药二甲双胍抑制肝糖产生改善病人高血糖的作用与AMPK激活有关,提示靶向AMPK可能是预防和治疗多种慢性疾病的有效策略之一。文中从AMPK的结构与活性、AMPK在糖代谢调控中的作用和AMPK在血脂代谢调控中的作用3个方面综述了AMPK研究的进展,旨在为糖脂代谢调控的基础和临床研究提供依据。

Adenosine 5’-monophosphate-activated protein activated protein kinase(AMPK),a heterotrimeric complex,is an important kinase to regulate glycolipid metabolism and energy balance involved in a variety physiological processes in human body.Many research indicated that the function and activity of AMPK were closely related to inflammation,diabetes and cancers.Recent reports show that inhibition of metformin(a first-line drug)on hepatic glucose in patients with hyperglycemia is associated with AMPK pathway,suggesting that targeting AMPK may be one of the effective strategies for the prevention and treatment of a variety of chronic diseases.Here,we review research progress on the structure,activation and regulation of AMPK in glycolipid metabolism to provide an insight into the basic and clinical research of diabetes therapy.