黑色素生成信号通路研究进展

Research progress in melanogenesis signaling pathway

黑色素生成是一种在黑色素细胞中产生黑色素的生物合成途径,涉及一系列复杂的酶催化和化学催化反应。主要有5条信号通路参与调控,其中小眼相关转录因子(Microphthalmia-associated transcription factor,MITF)是各个通路的重要靶标。此外,许多细胞因子也参与调控黑色素生成,在黑色素细胞的发育、增殖、分化、迁移过程中发挥重要作用。结合课题组研究成果,发现多金属氧酸盐可作为一种潜在的黑色素抑制剂用于切断黑色素生成途径。因此,文中对黑色素生成信号通路作用机制进行综述,并简单介绍已报道的相关通路调控因子,以期有助于多金属氧酸盐在黑色素生成途径中的应用研究。

Melanogenesis is a biosynthetic pathway to produce melanin pigment in melanocyte,involving a series of intricate enzymatic and chemical catalyzed reactions.Melanogenesis involves five signaling pathways that converge on microphthalmia-associated transcription factor.In addition,many cytokines,involved in the regulation of melanogenesis,play an important role in the development,proliferation,differentiation and migration of melanocytes.Polyoxometalate can be used as a potential inhibitor of melanin production.Hence,this paper reviews the signaling pathways of melanogenesis and their regulatory mechanism,to apply polyoxometalates in the melanin production pathway,and briefly introduces the regulatory factors of related pathways.