口服胰酶胶囊对全胃切除患者术后生活质量的意义

Significance of oral pancreatin enzyme capsules on life quality of patients with total gastrectomy

目的:探讨口服胰酶胶囊对全胃切除患者术后生活质量的意义。方法选取2012年12月~2013年12月在南阳市中心医院进行治疗的90例全胃切除患者,随机分为胰酶组和对照组,每组45例,对照组给予常规治疗,胰酶组在常规治疗基础上术后3周给予胰酶胶囊。比较2组患者术后给药前、给药6个月时EORTC QLQ-C30评分、korenaga评分及粪便脂肪含量。结果 2组患者术后给药前评分、korenaga评分及粪便脂肪含量无显著性差异;给药6个月后胰酶组的EORTC QLQ-C30功能量表中角色功能、情绪功能评分显著高于对照组,差异具有统计学意义(P<0.05);胰酶组在EORTC QLQ-C30单项量表中疲劳、食欲丧失、恶心呕吐、腹泻评分显著低于对照组,差异具有统计学意义(P<0.05);胰酶组在korenaga量表中的食欲下降、餐后胀饱感、失眠、体重下降程度显著低于对照组,差异具有统计学意义(P<0.05);胰酶组24 h及72 h粪便脂肪含量低于对照组,差异具有统计学意义(P<0.05);胰酶组24 h粪便脂肪含量>7 g的患者例数低于对照组,差异具有统计学意义(P<0.05)。结论口服胰酶胶囊可明显改善全胃切除患者术后的生活质量,值得临床推广。

Objective To explore the clinical significance of oral pancreatin capsules for patients after total gastrectomy.Methods Ninety cases of total gastrectomy patients in Nanyang City Center Hospital were selected and randomly divided into trypsin group and control group,with 45 patients in each group.The control group were treated by conventional therapy,and the patients of trypsin group were treated by pancreatin capsules on the basis of conventional therapy after 3 weeks postoperation.Scores of EORTC QLQ-C30,korenaga and fecal fat contents were compared between two groups six months postoperation.Results No statistically significant difference was found in the scoring system of EORTC QLQ-C30,korenaga and fecal fat contents in two groups before administered,The score of role function,emotional function and overall health status in the scoring system of EORTC QLQ-C30 of patients in trypsin group were higher than control group after 6 months administration.The differences were statistically significant (P<0.05 ).The score of fatigue,loss of appetite,nausea,vomiting,diarrhea in the scoring system of EORTC QLQ-C30 of patients in trypsin group were lower than control group after 6 months administration.The differences were statistically significant (P<0.05).The loss of appetite,swelling postprandial satiety,insomnia and the extent of weight loss in the scoring system of korenagain trypsin group were lower than control group after 6 months administration.The differences were statistically significant (P<0.05 ).The fecal fat contentsin trypsin group were lower than control group at 24 h and 72 h.The differences were statistically significant (P<0.05).The cases of 24h fecal fat content>7g in trypsin group was lower than control group at 24 h.The differences were statistically significant (P<0.05).Conclusion Oral pancreatin capsules could significantly improve the quality of life of patients after total gastrectomy, which is worthy of promoting.