α干扰素治疗慢性乙型肝炎的副作用及临床意义研究

Side effects of interferon α in treatment of chronic hepatitis B and its clinical significance study

目的探讨α干扰素(interferonα,IFN-α)治疗慢性乙型肝炎的副作用,并分析其临床治疗意义。方法选择2010年12月~2011年12月于吉林农业大学医院接受诊疗的164例慢性乙型肝炎患者作为研究对象,回顾性分析上述患者的临床资料,78例患者使用阿德福韦酯治疗(A组),86例患者使用长效干扰素α聚乙二醇化干扰素治疗(B组),观察2种干扰素药物的临床疗效和副反应。结果 B组患者乙肝表面抗原(HBsAg)的转阴率和乙肝病毒DNA(HBV DNA)转阴率分别为4.65%和59.30%,A组上述指标转阴率为2.56%和41.03%,经统计2组患者HBV DNA转阴率差异有统计学意义(P<0.05),且B组的肝功能改善效果明显好于A组;接受IFN-α治疗后,2组患者均出现副反应,包括发热、白细胞减少、中性粒细胞减少、抑郁、失眠等,2组的副反应发生率比较差异无统计学意义。结论 IFN-α是治疗慢性乙型肝炎的有效抗病毒药物,长效干扰素的疗效更为显著,但用药过程中会出现副反应,临床治疗时需要加强相关方面的预防和护理。

Objective To investigate the side effects of interferonαin treatment of chronic hepatitis B,and the analysis of its clinical significance. Methods 164 cases of patients with chronic hepatitis B were selected as research objects,who received medical treatment in Hospital of Jilin Agricultural University from December 2010 to December 2011.Clinical data of these patients was retrospectively analyzed.Adefovir dipivoxil was applied to 78 patients(group A),and peginterferon-α(PEG)was used in 86 patients(group B).Then efficacy and side effects of two interferon drug were observed.Results The HBsAg and HBV DNA negative rates of patients in group B was 4.65% and 59.30%,respectively.The negative rates of group A were 2.56% and 43.03%.HBV DNA negative rate of both groups had a significant difference by statistics(P<0.05 ),and improving effect of liver function of group B was also better than group A.After receiving IFN-αtreatment,patients of both groups all appeared side effects,including fever, leukopenia,neutropenia,depression and insomnia.The side effects incidence of both groups didn''t show significant difference.Conclusion IFN-αis an effective antiviral drugs for chronic hepatitis B.long-acting interferon has a better efficacy,but this drug also lead to side effect easily.Therefore,it is essential to strengthen the relevant prevention and care in the clinical treatment.