苦参碱辅助治疗对男性肝硬化患者性激素水平、金属离子含量及可溶性肿瘤坏死因子受体的影响

Effect of matrine on sex hormone level,metal ion content and soluble tumor necrosis factor receptor in male patients with liver cirrhosis

目的探讨苦参碱辅助治疗对男性肝硬化患者性激素水平、金属离子含量及可溶性肿瘤坏死因子受体的影响。方法选取南阳市中心医院已确诊为肝硬化失代偿期的男性患者70例,随机分为实验组和对照组,各35例,在常规治疗基础上,实验组给予苦参碱氯化钠注射液250 m L,每天1次静点;对照组给予等量0.9%氯化钠注射液,每天1次静点。治疗4周。治疗前后分别检测2组患者的肝功能、性激素水平、金属离子含量、可溶性肿瘤坏死因子受体指标。结果与对照组比较,实验组患者血清肝酶及总胆红素显著较降低(P<0.05),血清睾酮含量较高(P<0.05),雌二醇水平较低(P<0.05);血清锌、铁、镁含量较高,锰含量较低(P<0.05);血清可溶性肿瘤坏死因子受体s TNFRⅠ、s TNFRⅡ水平较低(P<0.05)。结论苦参碱辅助治疗能够调节男性肝硬化患者性激素水平及金属离子含量,降低可溶性肿瘤坏死因子受体的水平,改善患者肝功能。

Objective To analyse the effect of matrine on sex hormone level, metal ion content and soluble tumor necrosis factor receptor in male patients with liver cirrhosis.Methods 70 cases male patients diagnosed with liver cirrhosis of decompensation period were selected in the hospital and randomly divided into experimental group and control group, 35 cases in each group.The experimental group were treated with 250 mL matrine sodium chloride injection on the basis of conventional treatment and the control group were given equal 0.9%sodium chloride injection, once a day, intravenous drip for a consecutive treatment of 4 weeks.The liver function, sex hormone levels, metal ion content, and soluble tumor necrosis factor receptor indicators were detected before and after treatment in two groups.ResuIts Compared with control group, serum liver enzymes and total bilirubin in experimental group decreased (P<0.05);the content of serum testosterone increased and estradiol levels decreased (P<0.05);serum zinc, iron and magnesium content increased, manganese content decreased (P<0.05); serum soluble tumor necrosis factor receptor levels decreased (P<0.05). ConcIusion Matrine adjuvant therapy could regulate the level of sex hormone and metal ion in male patients with liver cirrhosis, reduce the level of soluble tumor necrosis factor receptor, improve liver function in patients with cirrhosis.