叶酸联合气滞胃痛颗粒对Hp阳性慢性萎缩性胃炎患者血清胃泌素、sIL-2R及免疫功能影响

Effect of folic acid combined with Qizhi Weitong granule on serum gastrin,sIL-2R and immune function in chronic atrophic gastritis patients of Hp positive

目的探讨叶酸联合气滞胃痛颗粒对Hp阳性慢性萎缩性胃炎患者血清胃泌素、sIL-2R及免疫功能的影响研究。方法收集贵州省毕节市第一人民医院收治的Hp阳性慢性萎缩性胃炎患者46例,根据用药不同分为对照组和实验组,每组各23例,对照组患者在常规用药的基础上给予叶酸片,实验组在对照组的基础上给予气滞胃痛颗粒,治疗连续3个月。治疗结束后,对所有患者的血清胃泌素、sIL-2R及T细胞亚群水平进行检测。结果治疗后与对照组比较,实验组血清胃泌素水平较高(P<0.05),sIL-2R水平较低(P<0.05),CD4+T、CD4+T/CD8+T较高(P<0.05),CD8+T水平较低(P<0.05)。结论叶酸联合气滞胃痛颗粒能够显著升高Hp阳性慢性萎缩性胃炎患者血清胃泌素水平、降低s IL-2R水平,上升CD4+T水平、降低CD8+T水平,对临床有指导意义。

Objective To investigate folic acid combined with Qizhi Weitong granule on serum gastrin, sIL-2R and immune function in chronic atrophy gastritis patients of Hp positive.Methods 46 cases with Hp positive chronic atrophy gastritis were selected and randomly divided into two groups according to different treatment, 23 cases in each group.The control group were given folic acid tablet on the basis of conventional treatment, and the experimental group were treated on the basis of control group combined with Qizhi Weitong granule.The patients in two groups were all treated for three months.Serum gastrin, sIL-2R and T cell subsets levels were detected after treatment.ResuIts Compared with control group after treatment, the serum gastrin level of experimental group was higher (P<0.05), sIL-2R level was lower (P<0.05), CD4 +T, CD4 +T/CD8 +T were higher (P<0.05), and CD8 +T level was lower ( P<0.05 ) .ConcIusion Folic acid combined with Qizhi Weitong granule could significantly increase serum gastrin and CD4 +T level and reduce sIL-2R and CD8 +T level in chronic atrophy gastritis patients of Hp positive, as a guidance for clinical.